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Whole-Body Imaging ...
Whole-Body Imaging of Tissue-specific Insulin Sensitivity and Body Composition by Using an Integrated PET/MR System: A Feasibility Study
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- Johansson, Emil (författare)
- Uppsala universitet,Radiologi,Centrum för klinisk forskning i Sörmland (CKFD),Uppsala Örebro-Reg Res Council, Uppsala
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- Lubberink, Mark (författare)
- Uppsala universitet,Radiologi
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- Heurling, Kerstin, 1982- (författare)
- Uppsala universitet,Radiologi
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- Eriksson, Jan W. (författare)
- Uppsala universitet,Klinisk diabetologi och metabolism
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- Skrtic, Stanko, 1970 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,AstraZeneca R&D, Gothenburg; Sahlgrenska Academy at Gothenburg University, Gothenburg
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- Ahlström, Håkan, 1953- (författare)
- Uppsala universitet,Radiologi,Antaros Medical, Mölndal
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- Kullberg, Joel, 1979- (författare)
- Uppsala universitet,Radiologi,Antaros Medical, Mölndal
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(creator_code:org_t)
- Radiological Society of North America (RSNA), 2018
- 2018
- Engelska.
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Ingår i: Radiology. - : Radiological Society of North America (RSNA). - 0033-8419 .- 1527-1315. ; 286:1, s. 271-278
- Relaterad länk:
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https://pubs.rsna.or...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Purpose: To develop, evaluate, and demonstrate the feasibility of a whole-body protocol for simultaneous assessment of tissue-specific insulin-mediated fluorine 18 (F-18) fluorodeoxyglucose (FDG) influx rates, tissue depots, and whole-body insulin sensitivity (referred to as the M value). Materials and Methods: An integrated positron emission tomography (PET)/magnetic resonance (MR) imaging system combined with hyperinsulinemic euglycemic clamp (HEC) was used. Dynamic whole-body PET imaging was used to determine the insulin-mediated F-18-FDG tissue influx rate (K-i) in the whole-body region by using the Patlak method. M value was determined with the HEC method at PET imaging. Tissue depots were quantified by using water-fat separated MR imaging and manual segmentations. Feasibility of the imaging protocol was demonstrated by using five healthy control participants and five patients with type 2 diabetes. Associations between M value and K-i were studied in multiple tissues by using the Pearson correlation. Results: Positive correlations were found between M value and K-i in multiple tissues: the gluteus muscle (r = 0.875; P = .001), thigh muscle (r = 0.903; P < .001), calf muscle (r = 0.825; P = .003), and abdominal visceral adipose tissue (r = 0.820; P = .004). A negative correlation was found in the brain (r = 0.798; P = .006). The MR imaging-based method for quantification of tissue depots was feasible for determining adipose tissue volumes and fat fractions. Conclusion: This PET/MR imaging protocol may be feasible for simultaneous assessment of tissue-specific insulin-mediated F-18-FDG influx rates, tissue depots, and M value. (C) RSNA, 2017
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- impaired glucose-tolerance
- skeletal-muscle
- f-18-fdg pet
- metabolism
- resistance
- humans
- depots
- blood
- liver
- Radiology
- Nuclear Medicine & Medical Imaging
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Johansson, Emil
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Lubberink, Mark
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Heurling, Kersti ...
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Eriksson, Jan W.
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Skrtic, Stanko, ...
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Ahlström, Håkan, ...
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Kullberg, Joel, ...
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