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- Hernroth, BodilMan and Biosphere Health (MABH),Royal Swedish Academy of Sciences (author)
Manganese inhibits viability of prostate cancer cells
- Article/chapterEnglish2018
Publisher, publication year, extent ...
- 2018-01-02
- Anticancer Research USA Inc.2018
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/264585
- https://gup.ub.gu.se/publication/264585URI
- https://doi.org/10.21873/anticanres.12201DOI
- oai:researchportal.hkr.se/admin:publications/e2ebe8a9-9c86-4e38-a697-879f164d52edURI
Supplementary language notes
- Language:English
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- SwePubSwePub
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Notes
- Background/Aim: Androgen deprivation therapy is usually in the initial phase a successful treatment for prostate cancer but eventually most patients develop androgen-independent metastatic disease. This study investigated if manganese (Mn) reduces viability of prostate cancer via induction of apoptosis. Materials and Methods: The prostate cancer cell lines PC3, DU145 and LNCaP underwent dose- and time-dependent screening of viability, analyzed by the 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl-tetrazolium bromide assay. Flow cytometry was used for the cell-cycle and apoptosis analyses. Intracellular Mn concentration was measured using inductively coupled plasma-mass spectrometry. Results: At Mn concentrations of 200-1000 µM, the effect on viability was most pronounced in PC3 followed by LNCaP cells. These cell lines also showed higher intracellular concentration of Mn compared to DU145. In all cell lines, Mn increased the proportion of cells arrested in the G0/G1 phase and induced apoptosis. Conclusion: To our knowledge, this is the first report demonstrating Mn as a potential agent in prostate cancer therapy.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- Apoptosis
- Cell viability
- DU145
- LNCaP
- Manganese
- PC3
- Prostate cancer
- antineoplastic agent
- cell cycle
- cell survival
- drug effects
- human
- male
- prostate tumor
- tumor cell line
- Antineoplastic Agents
- Cell Line
- Tumor
- Humans
- Prostatic Neoplasms
Added entries (persons, corporate bodies, meetings, titles ...)
- Holm, I.Man and Biosphere Health (MABH) (author)
- Gondikas, Andreas P.,1981Gothenburg University,Göteborgs universitet,Institutionen för marina vetenskaper,Department of marine sciences,University of Gothenburg(Swepub:gu)xgonan (author)
- Tassidis, H.Man and Biosphere Health (MABH) (author)
- Man and Biosphere Health (MABH)Royal Swedish Academy of Sciences (creator_code:org_t)
Related titles
- In:Anticancer Research: Anticancer Research USA Inc.38:1, s. 137-1450250-70051791-7530
Internet link
- http://ar.iiarjournals.org/content/38/1/137.full.pdf
- https://gup.ub.gu.se/publication/264585
- https://doi.org/10.21873/anticanres.12201
- oai:researchportal.hkr.se/admin:publications/e2ebe8a9-9c86-4e38-a697-879f164d52ed
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