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Search: id:"swepub:oai:gup.ub.gu.se/264628" > Impact of Thrombus ...

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  • Angerås, Oskar,1976Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden; Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrenska University Hospital,Gothenburg Univ, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden. (author)

Impact of Thrombus Aspiration on Mortality, Stent Thrombosis, and Stroke in Patients with ST-Segment-Elevation Myocardial Infarction: A Report From the Swedish Coronary Angiography and Angioplasty Registry

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • John Wiley & Sons,2018

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/264628
  • https://gup.ub.gu.se/publication/264628URI
  • https://doi.org/10.1161/JAHA.117.007680DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:137880695URI
  • https://lup.lub.lu.se/record/9076777e-bfbe-4e11-9171-94d8b885d5bcURI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-66406URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-351061URI

Supplementary language notes

  • Language:English

Part of subdatabase

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies:ALF Västra Götaland  University of Gothenburg, Sweden  ALFGBG 141131 
  • Background-Thrombus aspiration is still being used in a substantial number of patients despite 2 large randomized clinical trials showing no favorable effect of routine thrombus aspiration during primary percutaneous coronary intervention in patients with STsegment- elevation myocardial infarction. The aim of this observational study was to evaluate the impact of thrombus aspiration on mortality, stent thrombosis, and stroke using all available data from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR). Methods and Results--We identified 42 829 consecutive patients registered in SCAAR between January 2005 and September 2014 who underwent percutaneous coronary intervention for ST-segment-elevation myocardial infarction. Thrombus aspiration was used in 25% of the procedures. We used instrumental variable analysis with administrative healthcare region as the treatmentpreference instrumental variable to evaluate the effect of thrombus aspiration on mortality, stent thrombosis, and stroke. Thrombus aspiration was not associated with mortality at 30 days (risk reduction: -1.2; 95% confidence interval [CI] , -5.4 to 3.0; P=0.57) and 1 year (risk reduction: -2.4; 95% CI, -7.6 to 3.0; P=0.37). Thrombus aspiration was associated with a lower risk of stent thrombosis both at 30 days (risk reduction: -2.7; 95% CI, -4.1 to -1.4; P < 0.001) and 1 year (risk reduction: -3.5; 95% CI, -5.3 to -1.7; P < 0.001). In-hospital stroke and neurologic complications did not differ between groups (risk reduction: 0.1; 95% CI, -0.8 to 1.1; P=0.76). Conclusions--Mortality was not different between the groups. Thrombus aspiration was associated with decreased risk of stent thrombosis. Our study provides important evidence for the external validity of previous randomized studies regarding mortality.

Subject headings and genre

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  • Haraldsson, IngerGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden; Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrenska University Hospital,Gothenburg Univ, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.(Swepub:gu)xharin (author)
  • Redfors, BjörnGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden; Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrenska Academy,Gothenburg Univ, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.(Swepub:gu)xredbj (author)
  • Fröbert, Ole,1964-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology,Orebro Univ Hosp, Dept Cardiol, Gothenburg, Sweden.(Swepub:oru)oft (author)
  • Petursson, Petur,1973Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden; Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrenska University Hospital,Gothenburg Univ, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.(Swepub:gu)xpetpe (author)
  • Albertsson, Per,1956Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden; Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrenska Academy,Gothenburg Univ, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.(Swepub:gu)xalbep (author)
  • Ioanes, DanGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden; Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrenska Academy,Gothenburg Univ, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden. (author)
  • Odenstedt, Jacob,1968Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden; Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrenska Academy,Gothenburg Univ, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.(Swepub:gu)xodeja (author)
  • Olsson, HansDepartment of Cardiology, Karlstad Hospital, Karlstad, Sweden,Karlstad Hosp, Dept Cardiol, Karlstad, Sweden. (author)
  • Witt, NilsKarolinska Institutet,Karolinska University Hospital,Department of Cardiology, South Hospital Stockholm, Stockholm, Sweden,South Hosp Stockholm, Dept Cardiol, Stockholm, Sweden. (author)
  • Rück, AndreasKarolinska Institutet,Department of Cardiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden,Karolinska Univ Hosp, Karolinska Inst, Dept Cardiol, Stockholm, Sweden. (author)
  • Millgård, JonasDepartment of Cardiology, Sunderby Hospital, Sunderbyn, Sweden,Sunderby Hosp, Dept Cardiol, Sunderbyn, Sweden. (author)
  • Nilsson, JohanNorrland University Hospital,Department of Cardiology, Heart Centre, Umeå University Hospital, Umeå, Sweden,Umea Univ Hosp, Dept Cardiol, Heart Ctr, Umea, Sweden. (author)
  • Persson, JonasKarolinska Institutet,Department of Cardiology, Danderyd University Hospital, Stockholm, Sweden,Danderyd Hosp, Dept Cardiol, Stockholm, Sweden. (author)
  • Söderbom, Måns,1971University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för nationalekonomi med statistik,Department of Economics,Department of Economics, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Dept Econ, Gothenburg, Sweden.(Swepub:gu)xsodem (author)
  • Wedel, HansGothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Health Metrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Hlth Metr, Sahlgrenska Acad, Gothenburg, Sweden.(Swepub:gu)xwedha (author)
  • Erlinge, DavidLund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Department of Cardiology, Lund University, Lund, Sweden,Lund Univ, Dept Cardiol, Lund, Sweden.(Swepub:lu)kard-der (author)
  • James, Stefan,1964-Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)stjam367 (author)
  • Råmunddal, Truls,1973Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden; Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrenska University Hospital,Gothenburg Univ, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.(Swepub:gu)xramtr (author)
  • Omerovic, Elmir,1968Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden; Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrenska University Hospital,Gothenburg Univ, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.(Swepub:gu)xomeel (author)
  • Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin (creator_code:org_t)

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  • In:Journal of the American Heart Association: John Wiley & Sons7:12047-9980

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