Integrated insights into the role of alpha-melanocyte stimulatory hormone in the control of food intake and glycaemia

• Identifying peptide hormones with multipotent actions on both weight and glycaemia can have a significant impact on therapeutic options in the treatment of obesity and diabetes. This has been exemplified by recent advances involving pharmacological exploitation of glucagon-like peptide 1 biology. Herein, we summarise evidence supporting the potential candidacy in this light of alpha-melanocyte stimulatory hormone, an endogenous peptide hormone and a breakdown product of the neuropeptide pro-opiomelanocortin. We reference its well described central actions in the control of food intake and moreover highlight new data pointing to an important role for this peptide hormone in the periphery, in relation to glycaemic control.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Nyckelord

Diabetes

Obesity

Hormones

Pituitary

Skeletal muscle

Hypothalamus

agouti-related protein

human melanocortin-4 receptor

tumor-necrosis-factor

insulin-resistance

glucose-homeostasis

signal-transduction

biological-activity

plasma-levels

agonist mtii

weight-loss

Biochemistry & Molecular Biology

Endocrinology & Metabolism

Pharmacology & Pharmacy

iences

v361

p1265

ar ra

1995

proceedings of the national academy of sciences of the united states of

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