WFRF:(Lotta L. A.)
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- Mardinoglu, Adil,1982KTH,Science for Life Laboratory, SciLifeLab (author)
Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes
- Article/chapterEnglish2018
Publisher, publication year, extent ...
- Elsevier BV,2018
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/265450
- https://gup.ub.gu.se/publication/265450URI
- https://doi.org/10.1016/j.ebiom.2017.12.008DOI
- https://research.chalmers.se/publication/505754URI
- https://research.chalmers.se/publication/501356URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-224059URI
Supplementary language notes
- Language:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- QC 20180316
- Branched-chain amino acids (BCAAs) metabolite, 3-Hydroxyisobutyric acid (3-HIB) has been identified as a secreted mediator of endothelial cell fatty acid transport and insulin resistance (IR) using animal models. To identify if 3-HIB is a marker of human IR and future risk of developing Type 2 diabetes (T2D), we measured plasma levels of 3-HIB and associated metabolites in around 10,000 extensively phenotyped individuals. The levels of 3-HIB were increased in obesity but not robustly associated with degree of IR after adjusting for BMI. Nevertheless, also after adjusting for obesity and plasma BCAA, 3-HIB levels were associated with future risk of incident T2D. We also examined the effect of 3-HIB on fatty acid uptake in human cells and found that both HUVEC and human cardiac endothelial cells respond to 3-HIB whereas human adipose tissue-derived endothelial cells do not respond to 3-HIB. In conclusion, we found that increased plasma level of 3-HIB is a marker of future risk of T2D and 3-HIB may be important for the regulation of metabolic flexibility in heart and muscles.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Annan klinisk medicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Other Clinical Medicine hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
- 3-Hydroxyisobutyric acid (3-HIB)
- Branched-chain amino acids (BCAAs)
- T2D
- Insulin resistance
- Insulin
- insulin sensitivity
- glucose-tolerance
- cardiovascular-disease
- metabolic signature
- mannose levels
- resistance
- obesity
- risk
- General & Internal Medicine
- Research & Experimental Medicine
- Insulin secretion
Added entries (persons, corporate bodies, meetings, titles ...)
- Gogg, Silvia,1962Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg(Swepub:gu)xgogsi (author)
- Lotta, L. A.University Of Cambridge (author)
- Stancakova, A. (author)
- Nerstedt, Annika,1960Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg(Swepub:gu)xneran (author)
- Borén, Jan,1963Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg(Swepub:gu)xborej (author)
- Bluher, M.Universität Leipzig,Leipzig University (author)
- Ferrannini, E. (author)
- Langenberg, C.University Of Cambridge (author)
- Wareham, N. J.University Of Cambridge (author)
- Laakso, M.Itä-Suomen Yliopisto,University of Eastern Finland (author)
- Smith, Ulf,1943Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg(Swepub:gu)xsmiul (author)
- KTHScience for Life Laboratory, SciLifeLab (creator_code:org_t)
Related titles
- In:Ebiomedicine: Elsevier BV27, s. 151-1552352-3964
Internet link
- http://www.thelancet.com/article/S2352396417304899/pdf
- https://research.chalmers.se/publication/501356/file/501356_Fulltext.pdfFULLTEXT
- https://gup.ub.gu.se/publication/265450
- https://doi.org/10.1016/j.ebiom.2017.12.008
- https://research.chalmers.se/publication/505754
- https://research.chalmers.se/publication/501356
- https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-224059
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