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  • Allin, K. H. (author)

Aberrant intestinal microbiota in individuals with prediabetes

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-01-29
  • Springer Science and Business Media LLC,2018

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/265504
  • https://gup.ub.gu.se/publication/265504URI
  • https://doi.org/10.1007/s00125-018-4550-1DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-146199URI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Aims/hypothesis Individuals with type 2 diabetes have aberrant intestinal microbiota. However, recent studies suggest that metformin alters the composition and functional potential of gut microbiota, thereby interfering with the diabetes-related microbial signatures. We tested whether specific gut microbiota profiles are associated with prediabetes (defined as fasting plasma glucose of 6.1-7.0 mmol/l or HbA(1c) of 42-48 mmol/mol [6.0-6.5%]) and a range of clinical biomarkers of poor metabolic health. Methods In the present case-control study, we analysed the gut microbiota of 134 Danish adults with prediabetes, overweight, insulin resistance, dyslipidaemia and low-grade inflammation and 134 age-and sex-matched individuals with normal glucose regulation. Results We found that five bacterial genera and 36 operational taxonomic units (OTUs) were differentially abundant between individuals with prediabetes and those with normal glucose regulation. At the genus level, the abundance of Clostridium was decreased (mean log(2) fold change -0.64 (SEM 0.23), p(adj) = 0.0497), whereas the abundances of Dorea, [ Ruminococcus], Sutterella and Streptococcus were increased (mean log(2) fold change 0.51 (SEM 0.12), p(adj) = 5 x 10(-4); 0.51 (SEM 0.11), p(adj) = 1 x 10-4; 0.60 (SEM 0.21), p(adj) = 0.0497; and 0.92 (SEM0.21), padj = 4 x 10(-4), respectively). The two OTUs that differed the most were a member of the order Clostridiales (OTU 146564) and Akkermansia muciniphila, which both displayed lower abundance among individuals with prediabetes (mean log(2) fold change -1.74 (SEM0.41), p(adj) = 2 x 10(-3) and -1.65 (SEM0.34), p(adj) = 4 x 10(-4), respectively). Faecal transfer from donors with prediabetes or screen-detected, drug-naive type 2 diabetes to germfree Swiss Webster or conventional C57BL/6 J mice did not induce impaired glucose regulation in recipient mice. Conclusions/interpretation Collectively, our data show that individuals with prediabetes have aberrant intestinal microbiota characterised by a decreased abundance of the genus Clostridium and the mucin-degrading bacterium A. muciniphila. Our findings are comparable to observations in overt chronic diseases characterised by low-grade inflammation.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Tremaroli, V. (author)
  • Caesar, Robert,1973Gothenburg University,Göteborgs universitet,Center for Cardiovascular and Metabolic Research (CMR),Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xcaero (author)
  • Jensen, B. A. H. (author)
  • Damgaard, M. T. F. (author)
  • Bahl, M. I. (author)
  • Licht, T. R. (author)
  • Hansen, T. H. (author)
  • Nielsen, T. (author)
  • Dantoft, T. M. (author)
  • Linneberg, A. (author)
  • Jorgensen, T. (author)
  • Vestergaard, H. (author)
  • Kristiansen, K. (author)
  • Franks, Paul W.Umeå universitet,Avdelningen för medicin(Swepub:umu)pafr0003 (author)
  • Hansen, T. (author)
  • Bäckhed, Fredrik,1973Gothenburg University,Göteborgs universitet,Center for Cardiovascular and Metabolic Research (CMR),Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xbafre (author)
  • Pedersen, O. (author)
  • Göteborgs universitetCenter for Cardiovascular and Metabolic Research (CMR) (creator_code:org_t)

Related titles

  • In:Diabetologia: Springer Science and Business Media LLC61:4, s. 810-8200012-186X1432-0428

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