SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:gup.ub.gu.se/265510"
 

Sökning: onr:"swepub:oai:gup.ub.gu.se/265510" > Outcome and surviva...

  • Blimark, CecilieGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Sahlgrenska University Hospital,Univ Gothenburg, Sweden; Skane Univ Hosp, Sweden (författare)

Outcome and survival of myeloma patients diagnosed 2008-2015. Real-world data on 4904 patients from the Swedish Myeloma Registry

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • 2017-12-07
  • Ferrata Storti Foundation (Haematologica),2018

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/265510
  • https://gup.ub.gu.se/publication/265510URI
  • https://doi.org/10.3324/haematol.2017.178103DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-342992URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:137742475URI
  • https://lup.lub.lu.se/record/683ae0b7-c4dc-401f-a4fa-283f162154d2URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-147152URI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Epidemiology and outcome of myeloma are mainly reported from large university centers and collaborative groups, and do not represent 'real-world' patients. The Swedish Myeloma Registry is a prospective population-based registry documenting characteristics, treatment and outcome in newly diagnosed myeloma, including asymptomatic and localized forms, with the purpose of improving disease management and outcome. This report presents information on patients diagnosed between 2008 and 2015, including data on first-line treatment in patients diagnosed up to 2014, with a follow up until December 2016. We present age-adjusted incidence, patients' characteristics at baseline, treatment, response, and survival. Baseline data were available with a 97% coverage in 4904 patients (median age 71 years, males 70 years, females 73 years; 72% were 65 years or older), and at 1-year follow up in 3558 patients with symptomatic disease (92% of patients initially reported). The age-adjusted incidence was 6.8 myeloma cases per 100,000 inhabi-ants per year. Among initially symptomatic patients (n= 3988), 77% had osteolytic lesions or compression fractures, 49% had anemia, 18% impaired kidney function, and 13% hypercalcemia. High-dose therapy with autologous stem cell transplantation was given to 77% of patients aged up to 66 years, and to 22% of patients aged 66-70 years. In the study period, 68% received bortezomib, thalidomide, and/or lenalidomide as part of the first-line treatment, rising from 31% in 2008 to 81% in 2014. In active myeloma, the median relative survival of patients aged 65 years or under was 7.7 years, and 3.4 years in patients aged 66 years and over. Patients diagnosed with myeloma in more recent years were associated with significantly higher rates of complete or very good partial remission (P<0.05), and with a significantly higher survival, with a Hazard Ratio (HR) of 0.84 (95% CI: 0.77-0.92; P<0.05). There was a small, but significant survival benefit in patients treated at university hospitals (HR 0.93; 95% CI: 0.87-0.99; P<0.05). We report here on a near complete 'real-world' population of myeloma patients during an 8-year period; a period in which newer drugs were implemented into standard practice. The overall incidence and median age were both higher than in most previous studies, indicating a more complete coverage of older patients. Myeloma survival in Sweden is comparable to other large registry studies, and responses and survival improved during the study period.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Turesson, IngemarSkåne University Hospital, Lund-Malmö, Sweden(Swepub:lu)medf-itu (författare)
  • Genell, A.Regional Cancer Center Western Sweden,Western Sweden Hlth Care Reg, Sweden (författare)
  • Ahlberg, LuciaLinköping University Hospital,Region Östergötland, Hematologiska kliniken US(Swepub:liu)lucah64 (författare)
  • Bjorkstrand, B.Karolinska Institute,Karolinska Inst, Sweden (författare)
  • Carlson, KristinaUppsala universitet,Hematologi,Uppsala University Hospital,Uppsala Univ Hosp, Sweden(Swepub:uu)krica965 (författare)
  • Forsberg, K.Umeå University,Umeå Univ Hosp, Sweden (författare)
  • Juliusson, GunnarLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Lund Univ, Sweden(Swepub:lu)stem-gju (författare)
  • Linder, O.Örebro University Hospital,Örebro Univ Hosp, Sweden (författare)
  • Mellqvist, Ulf-Henrik,1961Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Sahlgrenska University Hospital,Univ Gothenburg, Sweden; Skane Univ Hosp, Sweden; Boras Hosp, Sweden (författare)
  • Nahi, H.Karolinska Institutet,Karolinska University Hospital,Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden (författare)
  • Kristinsson, S. Y.Karolinska University Hospital,University of Iceland,Karolinska Inst, Sweden; Univ Iceland, Iceland; Karolinska Univ Hosp, Sweden (författare)
  • Göteborgs universitetInstitutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Haematologica: Ferrata Storti Foundation (Haematologica)103:3, s. 506-5130390-60781592-8721

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy