Sökning: WFRF:(Magdalinou N. K.) >
CSF neurogranin or ...
CSF neurogranin or tau distinguish typical and atypical Alzheimer disease
-
Wellington, H. (författare)
-
Paterson, R. W. (författare)
-
Suarez-Gonzalez, A. (författare)
-
visa fler...
-
Poole, T. (författare)
-
Frost, C. (författare)
-
Sjobom, U. (författare)
-
Slattery, C. F. (författare)
-
Magdalinou, N. K. (författare)
-
Lehmann, M. (författare)
-
- Portelius, Erik, 1977 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
Fox, N. C. (författare)
-
- Blennow, Kaj, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
- Zetterberg, Henrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
Schott, J. M. (författare)
-
visa färre...
-
(creator_code:org_t)
- 2018-01-11
- 2018
- Engelska.
-
Ingår i: Annals of Clinical and Translational Neurology. - : Wiley. - 2328-9503. ; 5:2, s. 162-171
- Relaterad länk:
-
https://gup.ub.gu.se... (primary) (free)
-
visa fler...
-
https://onlinelibrar...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Objective: To assess whether high levels of cerebrospinal fluid neurogranin are found in atypical as well as typical Alzheimer's disease. Methods: Immunoassays were used to measure cerebrospinal fluid neurogranin in 114 participants including healthy controls (n=27), biomarker-proven amnestic Alzheimer's disease (n=68), and the atypical visual variant of Alzheimer's (n=19) according to international criteria. CSF total-tau, A beta 42, and neurofilament light concentrations were investigated using commercially available assays. All affected individuals had T1-weighted volumetric MR images available for analysis of whole and regional brain volumes. Associations between neurogranin, brain volumes, total-tau, A beta 42, and neurofilament light were assessed. Results: Median cerebrospinal fluid neurogranin concentrations were higher in typical and atypical Alzheimer's compared to controls (P<0.001 and P=0.005). Both neurogranin and total-tau concentrations, but not neurofilament light and A beta 42, were higher in typical Alzheimer's compared to atypical patients (P=0.004 and P=0.03). There were significant differences in the left hippocampus and right and left superior parietal lobules in atypical patients, which were larger (P=0.03) and smaller (P=0.001 and P<0.001), respectively, compared to typical patients. We found no evidence of associations between neurogranin and brain volumes but a strong association with total-tau (P<0.001) and a weaker association with neurofilament light (P=0.005). Interpretation: These results show significant differences in neurogranin and total-tau between typical and atypical patients, which may relate to factors other than disease topography. The differential relationships between neurogranin, total-tau and neurofilament light in the Alzheimer's variants, provide evidence for mechanistically distinct and coupled markers of neurodegeneration.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- posterior cortical atrophy
- cerebrospinal-fluid biomarkers
- neurofilament light
- cognitive impairment
- neuronal-activity
- synapse
- loss
- in-vivo
- dementia
- association
- sclerosis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Wellington, H.
-
Paterson, R. W.
-
Suarez-Gonzalez, ...
-
Poole, T.
-
Frost, C.
-
Sjobom, U.
-
visa fler...
-
Slattery, C. F.
-
Magdalinou, N. K ...
-
Lehmann, M.
-
Portelius, Erik, ...
-
Fox, N. C.
-
Blennow, Kaj, 19 ...
-
Zetterberg, Henr ...
-
Schott, J. M.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Neurovetenskaper
- Artiklar i publikationen
-
Annals of Clinic ...
- Av lärosätet
-
Göteborgs universitet