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Sökning: id:"swepub:oai:gup.ub.gu.se/265620" > Embolic strokes of ...

  • Martinez-Majander, N. (författare)

Embolic strokes of undetermined source in young adults: baseline characteristics and long-term outcome

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • 2018-01-19
  • Wiley,2018

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/265620
  • https://gup.ub.gu.se/publication/265620URI
  • https://doi.org/10.1111/ene.13540DOI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background and purposeEmbolic strokes of undetermined source (ESUS) are a recent entity, not yet thoroughly investigated in young stroke patients. The clinical characteristics and long-term risks of vascular events and all-cause mortality between young-onset ESUS and other aetiological subgroups were compared. MethodsPatients with ESUS were identified amongst the 1008 patients aged 15-49 years with first-ever ischaemic stroke in Helsinki Young Stroke Registry, and primary end-points were defined as recurrent stroke, composite vascular events and all-cause mortality. Cumulative 15-year risks for each end-point were analysed with life tables and adjusted risks were based on Cox proportional hazard analyses. ResultsOf the 971 eligible patients, 203 (20.9%) were classified as ESUS. They were younger (median age 40 years, interquartile range 32-46 vs. 45 years, 39-47), more often female (43.3% vs. 35.7%) and had fewer cardiovascular risk factors than other modified TOAST groups. With a median follow-up time of 10.1 years, ESUS patients had the second lowest cumulative risk of recurrent stroke and composite vascular events and lowest mortality compared to other TOAST groups. Large-artery atherosclerosis and small vessel disease carried significantly higher risk for recurrent stroke than did ESUS, whilst no difference appeared between cardioembolism from high-risk sources and ESUS. ConclusionsIn our cohort, ESUS patients were younger and had milder cardiovascular risk factor burden and generally better long-term outcome compared to other causes of young-onset stroke. The comparable risk of recurrent stroke between ESUS and high-risk sources of cardioembolism might suggest similarities in their pathophysiology.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Aarnio, K. (författare)
  • Pirinen, J. (författare)
  • Lumikari, T. (författare)
  • Nieminen, T. (författare)
  • Lehto, M. (författare)
  • Sinisalo, J. (författare)
  • Kaste, M. (författare)
  • Tatlisumak, TurgutGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xtatlt (författare)
  • Putaala, J. (författare)
  • Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:European Journal of Neurology: Wiley25:3, s. 535-5411351-51011468-1331

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