Search: id:"swepub:oai:gup.ub.gu.se/265789" >
Evolution of cerebr...
-
Førland, Marthe Gurine
(author)
Evolution of cerebrospinal fluid total α-synuclein in Parkinson's disease.
- Article/chapterEnglish2018
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/265789
-
https://gup.ub.gu.se/publication/265789URI
-
https://doi.org/10.1016/j.parkreldis.2018.01.018DOI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Cerebrospinal fluid (CSF) total α-synuclein is considered a potential biomarker for Parkinson's disease (PD), but little is known about the evolution of this marker during the course of the disease. Our objective was to investigate whether CSF total α-synuclein concentrations change over time and are associated with motor and cognitive function in PD.CSF total α-synuclein concentrations were quantified in 56 longitudinally followed PD patients, 27 of whom provided CSF repeatedly 2 and/or 4 years later. Another 18 subjects were included as controls. The samples were analyzed using two independent, validated ELISA methods: our recently developed and validated in-house ELISA and a commercial kit from BioLegend.CSF total α-synuclein levels did not distinguish PD patients from controls, displayed no substantial changes during a period of up to 4 years, and did not predict subsequent motor or cognitive decline. These findings were consistent for both analytical methods.Our findings do not support the clinical utility of total α-synuclein as a single diagnostic or prognostic biomarker in PD.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Öhrfelt, Annika,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xohrfa
(author)
-
Tysnes, Ole-Bjørn
(author)
-
Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka
(author)
-
Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe
(author)
-
Pedersen, Kenn Freddy
(author)
-
Alves, Guido
(author)
-
Lange, Johannes
(author)
-
Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
(creator_code:org_t)
Related titles
-
In:Parkinsonism & related disorders: Elsevier BV49, s. 4-81873-51261353-8020
Internet link
Find in a library
To the university's database
- By the author/editor
-
Førland, Marthe ...
-
Öhrfelt, Annika, ...
-
Tysnes, Ole-Bjør ...
-
Blennow, Kaj, 19 ...
-
Zetterberg, Henr ...
-
Pedersen, Kenn F ...
-
show more...
-
Alves, Guido
-
Lange, Johannes
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
- Articles in the publication
-
Parkinsonism & r ...
- By the university
-
University of Gothenburg