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Prognostic signific...
Prognostic significance of proteinuria in stroke patients treated with intravenous thrombolysis.
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Gensicke, H (author)
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Frih, A A (author)
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Strbian, D (author)
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Zini, A (author)
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Pezzini, A (author)
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Padjen, V (author)
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Haueter, M (author)
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Seiffge, D J (author)
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Mäkitie, L (author)
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Traenka, C (author)
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Poli, L (author)
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Martinez-Majander, N (author)
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Putaala, J (author)
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Bonati, L H (author)
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Sibolt, G (author)
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Giovannini, G (author)
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Curtze, S (author)
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Beslac-Bumbasirevic, L (author)
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Vandelli, L (author)
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Lyrer, P A (author)
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Nederkoorn, P J (author)
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- Tatlisumak, Turgut (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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Engelter, S T (author)
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(creator_code:org_t)
- 2016-11-10
- 2017
- English.
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In: European journal of neurology. - : Wiley. - 1468-1331 .- 1351-5101. ; 24:2, s. 262-269
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https://doi.org/10.1...
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Abstract
Subject headings
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- Proteinuria and estimated glomerular filtration rate (eGFR) are indicators of renal function. Whether proteinuria better predicts outcome than eGFR in stroke patients treated with intravenous thrombolysis (IVT) remains to be determined.In this explorative multicenter IVT register based study, the presence of urine dipstick proteinuria (yes/no), reduced eGFR (<60 ml/min/1.73 m2 ) and the coexistence of both with regard to (i) poor 3-month outcome (modified Rankin Scale score 3-6), (ii) death within 3 months and (iii) symptomatic intracranial hemorrhage (ECASS-II criteria) were compared. Unadjusted and adjusted odds ratios (ORs) with 95% confidence intervals were calculated.Amongst 3398 patients, 881 (26.1%) had proteinuria and 623 (18.3%) reduced eGFR. Proteinuria [ORadjusted 1.65 (1.37-2.00) and ORadjusted 1.52 (1.24-1.88)] and reduced eGFR [ORadjusted 1.26 (1.01-1.57) and ORadjusted 1.34 (1.06-1.69)] were independently associated with poor functional outcome and death, respectively. After adding both renal markers to the models, proteinuria [ORadjusted+eGFR 1.59 (1.31-1.93)] still predicted poor outcome whilst reduced eGFR [ORadjusted+proteinuria 1.20 (0.96-1.50)] did not. Proteinuria was associated with symptomatic intracranial hemorrhage [ORadjusted 1.54 (1.09-2.17)] but not reduced eGFR [ORadjusted 0.96 (0.63-1.62)]. In 234 (6.9%) patients, proteinuria and reduced eGFR were coexistent. Such patients were at the highest risk of poor outcome [ORadjusted 2.16 (1.54-3.03)] and death [ORadjusted 2.55 (1.69-3.84)].Proteinuria and reduced eGFR were each independently associated with poor outcome and death but the statistically strongest association appeared for proteinuria. Patients with coexistent proteinuria and reduced eGFR were at the highest risk of poor outcome and death.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Administration
- Intravenous
- Aged
- Aged
- 80 and over
- Female
- Glomerular Filtration Rate
- physiology
- Humans
- Intracranial Hemorrhages
- etiology
- Male
- Middle Aged
- Prognosis
- Proteinuria
- complications
- Stroke
- complications
- drug therapy
- Thrombolytic Therapy
- adverse effects
- Treatment Outcome
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Gensicke, H
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Frih, A A
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Strbian, D
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Zini, A
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Pezzini, A
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Padjen, V
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show more...
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Haueter, M
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Seiffge, D J
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Mäkitie, L
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Traenka, C
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Poli, L
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Martinez-Majande ...
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Putaala, J
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Bonati, L H
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Sibolt, G
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Giovannini, G
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Curtze, S
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Beslac-Bumbasire ...
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Vandelli, L
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Lyrer, P A
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Nederkoorn, P J
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Tatlisumak, Turg ...
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Engelter, S T
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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European journal ...
- By the university
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University of Gothenburg