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- Klingberg, Sofia,1979Linköpings universitet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för folkhälsoepidemiologi,Institute of Medicine, Department of Public Health and Community Medicine, Public Health Epidemiology Unit,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,University of Gothenburg, Gothenburg, Sweden (author)
Lower risk of hip fractures among Swedish women with large hips?
- Article/chapterEnglish2018
Publisher, publication year, extent ...
- 2018-01-27
- Springer Science and Business Media LLC,2018
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- LIBRIS-ID:oai:gup.ub.gu.se/266732
- https://gup.ub.gu.se/publication/266732URI
- https://doi.org/10.1007/s00198-017-4363-yDOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-147085URI
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- Language:English
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- Funding Agencies|Swedish Research Council FORTE, through its support of EpiLife Center of Excellence
- In women, a large hip circumference (HC) related to lower hip fracture risk, independent of age and regardless if HC was measured long before or closer to the fracture. In older women, body mass index (BMI) explained the protection. In postmenopausal women, HC has been suggested to inversely associate with hip fracture while this has not been investigated in middle-aged women. We examined the association between HC, measured at two different time points, and hip fracture in a Swedish female population-based sample monitored for incident hip fractures over many years. Baseline HC, measured in 1968 or 1974 (n = 1451, mean age 47.6 years), or the HC measures that were the most proximal before event or censoring (n = 1325, mean age 71.7 years), were used to assess the effects of HC on hip fracture risk in women participating in the Prospective Population Study of Women in Gothenburg. HC was parameterized as quintiles with the lowest quintile (Q1) as reference. Incident hip fractures over 45 years of follow-up (n = 257) were identified through hospital registers. Higher quintiles of HC at both baseline and proximal to event were inversely associated with hip fracture risk in age-adjusted models, but only baseline HC predicted hip fractures independently of BMI and other covariates (HR (95% CI) Q2, 0.85 (0.56-1.27); Q3, 0.59 (0.36-0.96); Q4, 0.57 (0.34-0.96); Q5, 0.58 (0.31-1.10)). A large HC is protective against hip fracture in midlife and in advanced age, but the association between proximal HC and hip fracture was explained by concurrent BMI suggesting that padding was not the main mechanism for the association. The independent protection seen in middle-aged women points to other mechanisms influencing bone strength.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Ortopedi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Orthopaedics hsv//eng
- Body mass index
- Hip circumference
- Hip fractures
- Longitudinal
- hormone replacement therapy
- bone-mineral density
- body-mass index
- postmenopausal women
- older women
- association
- circumference
- metaanalysis
- mortality
- obesity
- Endocrinology & Metabolism
- Body mass index; Hip circumference; Hip fractures; Longitudinal
Added entries (persons, corporate bodies, meetings, titles ...)
- Mehlig, Kirsten,1964Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för folkhälsoepidemiologi,Institute of Medicine, Department of Public Health and Community Medicine, Public Health Epidemiology Unit,Univ Gothenburg, Sweden(Swepub:gu)xmehki (author)
- Sundh, Valter,1950Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för folkhälsoepidemiologi,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Public Health and Community Medicine, Public Health Epidemiology Unit,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Univ Gothenburg, Sweden(Swepub:gu)xsunva (author)
- Lissner, Lauren,1956Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för folkhälsoepidemiologi,Institute of Medicine, Department of Public Health and Community Medicine, Public Health Epidemiology Unit(Swepub:gu)xlisla (author)
- Lissner, Lauren,1956Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för folkhälsoepidemiologi,Institute of Medicine, Department of Public Health and Community Medicine, Public Health Epidemiology Unit(Swepub:gu)xlisla (author)
- Göteborgs universitetInstitutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för folkhälsoepidemiologi (creator_code:org_t)
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- In:Osteoporosis International: Springer Science and Business Media LLC29:4, s. 927-9350937-941X1433-2965
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