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- Toombs, J. (author)
Amyloid β peptides are differentially vulnerable to preanalytical surface exposure, an effect incompletely mitigated by the use of ratios
- Article/chapterEnglish2018
Publisher, publication year, extent ...
- 2018-03-22
- Wiley,2018
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/267446
- https://gup.ub.gu.se/publication/267446URI
- https://doi.org/10.1016/j.dadm.2018.02.005DOI
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- Language:English
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Notes
- Introduction: We tested the hypothesis that the amyloid β (Aβ) peptide ratios are more stable than Aβ42 alone when biofluids are exposed to two preanalytical conditions known to modify measurable Aβ concentration. Methods: Human cerebrospinal fluid (CSF) and culture media (CM) from human cortical neurons were exposed to a series of volumes and polypropylene surfaces. Aβ42, Aβ40, and Aβ38 peptide concentrations were measured using a multiplexed electrochemiluminescence immunoassay. Data were analyzed using mixed models in R. Results: Decrease of measurable Aβ peptide concentrations was exaggerated in longer peptides, affecting the Aβ42:Aβ40 and Aβ42:Aβ38 ratios. However, the effect size of surface treatment was reduced in Aβ peptide ratios versus Aβ42 alone. For Aβ42:Aβ40, the effect was reduced by approximately 50% (volume) and 75% (transfer) as compared to Aβ42 alone. Discussion: Use of Aβ ratios, in conjunction with concentrations, may mitigate confounding factors and assist the clinical diagnostic process for Alzheimer's disease.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
- Alzheimer's disease
- Amyloid β ratio
- Cell culture media
- Cerebrospinal fluid
- Preanalytical factors
- Surface adsorption
Added entries (persons, corporate bodies, meetings, titles ...)
- Foiani, M. S. (author)
- Wellington, H. (author)
- Paterson, R. W. (author)
- Arber, C. (author)
- Heslegrave, A. (author)
- Lunn, M. P. (author)
- Schott, J. M. (author)
- Wray, S. (author)
- Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe (author)
- Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)
Related titles
- In:Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring: Wiley10, s. 311-3212352-8729
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