Positron emission tomography and computed tomographic (PET/CT) imaging for radiation therapy planning in anal cancer: A systematic review and meta-analysis

To improve the accuracy of chemoradiation therapy in anal cancer patients PET/CT is frequently used in the planning of radiation therapy. A systematic review was performed to assess impact on survival, quality of life, symptom score, change in target definition and treatment intention. Systematic literature searches were conducted in Medline, EMBASE, the Cochrane Library, and Centre for Reviews and Dissemination. Ten cross-sectional studies were identified. No data were available on survival or quality of life. The summary estimate of the proportion of patients in which PET/CT had an impact on the target definition, was 23% (95% CI 16;33). The corresponding summary estimate of a change in treatment intent from curative to palliative was 3% (95% CI 2;6). Almost one in four patients had a change in target definition, which supports the use of PET/CT in radiation therapy planning, but the consequence regarding survival and quality of life is still uncertain.

Alverbratt, Charlotte (författare)
Liljegren, Ann (författare)
Björkander, Emil (författare)
Strandell, Annika,1956 (författare)
Samuelsson, Ola,1952 (författare)
Palm, Stig,1964Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiofysik,Institute of Clinical Sciences, Department of Radiation Physics(Swepub:gu)xpalst (författare)
Hallqvist, Andreas,1973 (författare)
Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för radiofysik (creator_code:org_t)

Ingår i:Critical reviews in oncology/hematology: Elsevier BV126, s. 6-121040-8428

Av författaren/redakt...: Albertsson, Per, ...; Alverbratt, Char ...; Liljegren, Ann; Björkander, Emil; Strandell, Annik ...; Samuelsson, Ola, ...; visa fler...; Palm, Stig, 1964; Hallqvist, Andre ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

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