The Better Diabetes Diagnosis (BDD) study – A review of a nationwide prospective cohort study in Sweden

• The incidence of type 1 diabetes (T1D) in Sweden is one of the highest in the world. However, the possibility of other types of diabetes must also be considered. In addition, individuals with T1D constitute a heterogeneous group. A precise classification of diabetes is a prerequisite for optimal outcome. For precise classification, knowledge on the distribution of genetic factors, biochemical markers and clinical features in individuals with new onset of diabetes is needed. The Better Diabetes Diagnosis (BDD), is a nationwide study in Sweden with the primary aim to facilitate a more precise classification and diagnosis of diabetes in order to enable the most adequate treatment for each patient. Secondary aims include identification of risk factors for diabetes-related co-morbidities. Since 2005, data on almost all children and adolescents with newly diagnosed diabetes in Sweden are prospectively collected and including heredity of diabetes, clinical symptoms, levels of C peptide, genetic analyses and detection of autoantibodies. Since 2011, analyses of HLA profile, autoantibodies and C peptide levels are part of clinical routine in Sweden for all pediatric patients with suspected diagnosis of diabetes. In this review, we present the methods and main results of the BDD study so far and discuss future aspects.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Nyckelord

autoantibody

C peptide

glutamate decarboxylase 65 antibody

HLA antigen

insulin antibody

insulinoma associated 2 antibody

unclassified drug

zinc transporter 8 antibody

antibody detection

celiac disease

clinical feature

comorbidity

diabetes mellitus

disease classification

family history

genetic analysis

HLA typing

human

insulin dependent diabetes mellitus

non insulin dependent diabetes mellitus

pediatrics

Review

risk assessment

risk factor

Sweden

thyroid disease

Publikations- och innehållstyp

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