Search: L773:1932 7420 OR L773:1550 4131 >
Acute exercise remo...
Acute exercise remodels promoter methylation in human skeletal muscle
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Barres, R. (author)
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Yan, J. (author)
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- Egan, B. (author)
- Karolinska Institutet
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Treebak, J. T. (author)
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Rasmussen, M. (author)
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Fritz, T. (author)
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- Caidahl, Kenneth, 1949 (author)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Extern,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,External,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Krook, A. (author)
- Karolinska Institutet
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O'Gorman, D. J. (author)
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- Zierath, J. R. (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- English.
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In: Cell Metabolism. - : Elsevier BV. - 1550-4131 .- 1932-7420. ; 15:3, s. 405-11
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http://www.cell.com/...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- DNA methylation is a covalent biochemical modification controlling chromatin structure and gene expression. Exercise elicits gene expression changes that trigger structural and metabolic adaptations in skeletal muscle. We determined whether DNA methylation plays a role in exercise-induced gene expression. Whole genome methylation was decreased in skeletal muscle biopsies obtained from healthy sedentary men and women after acute exercise. Exercise induced a dose-dependent expression of PGC-1alpha, PDK4, and PPAR-delta, together with a marked hypomethylation on each respective promoter. Similarly, promoter methylation of PGC-1alpha, PDK4, and PPAR-delta was markedly decreased in mouse soleus muscles 45 min after ex vivo contraction. In L6 myotubes, caffeine exposure induced gene hypomethylation in parallel with an increase in the respective mRNA content. Collectively, our results provide evidence that acute gene activation is associated with a dynamic change in DNA methylation in skeletal muscle and suggest that DNA hypomethylation is an early event in contraction-induced gene activation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- Adult
- Animals
- DNA Methylation/genetics/physiology
- Exercise/*physiology
- Female
- Humans
- Male
- Mice
- Mice
- Inbred C57BL
- Muscle
- Skeletal/*metabolism
- Young Adult
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Barres, R.
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Yan, J.
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Egan, B.
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Treebak, J. T.
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Rasmussen, M.
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Fritz, T.
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show more...
-
Caidahl, Kenneth ...
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Krook, A.
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O'Gorman, D. J.
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Zierath, J. R.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Physiology
- Articles in the publication
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Cell Metabolism
- By the university
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University of Gothenburg
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Karolinska Institutet