Rare and Common Variants Conferring Risk of Tooth Agenesis

Search: WFRF:(Nawaz F.) > Rare and Common Var...

Jonsson, Lina,1982Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology (author)

We present association results from a large genome-wide association study of tooth agenesis (TA) as well as selective TA, including 1,944 subjects with congenitally missing teeth, excluding third molars, and 338,554 controls, all of European ancestry. We also tested the association of previously identified risk variants, for timing of tooth eruption and orofacial clefts, with TA. We report associations between TA and 9 novel risk variants. Five of these variants associate with selective TA, including a variant conferring risk of orofacial clefts. These results contribute to a deeper understanding of the genetic architecture of tooth development and disease. The few variants previously associated with TA were uncovered through candidate gene studies guided by mouse knockouts. Knowing the etiology and clinical features of TA is important for planning oral rehabilitation that often involves an interdisciplinary approach.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Odontologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Dentistry hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
genetics
molecular genetics
hypodontia
oligodontia
orofacial cleft(s)
odontogenesis
genome-wide association
3rd molar agenesis
ectodermal dysplasia
lateral incisor
permanent teeth
ectodysplasin-a
cleft-lip
prevalence
mutation
metaanalysis

Magnusson, T. E. (author)
Thordarson, A. (author)
Jonsson, T. (author)
Geller, F. (author)
Feenstra, B. (author)
Melbye, M. (author)
Nohr, E. A. (author)
Vucic, S. (author)
Dhamo, B. (author)
Rivadeneira, F. (author)
Ongkosuwito, E. M. (author)
Wolvius, E. B. (author)
Leslie, E. J. (author)
Marazita, M. L. (author)
Howe, B. J. (author)
Uribe, L. M. M. (author)
Alonso, I. (author)
Santos, M. (author)
Pinho, T. (author)
Jonsson, R. (author)
Audolfsson, G. (author)
Gudmundsson, L. (author)
Nawaz, M. S. (author)
Olafsson, S. (author)
Gustafsson, O. (author)
Ingason, A. (author)
Unnsteinsdottir, U. (author)
Bjornsdottir, G. (author)
Walters, G. B. (author)
Zervas, M. (author)
Oddsson, A. (author)
Gudbjartsson, D. F. (author)
Steinberg, S. (author)
Stefansson, H. (author)
Stefansson, K. (author)
Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för farmakologi (creator_code:org_t)

In:Journal of Dental Research: SAGE Publications97:5, s. 515-5220022-03451544-0591

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Dentistry

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.