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  • Espersen, A. D. L.Aarhus Univ Hosp Skejby, Dept Pediat, Aarhus, Denmark. (författare)

Acute myeloid leukemia (AML) with t(7;12)(q36;p13) is associated with infancy and trisomy 19: Data from Nordic Society for Pediatric Hematology and Oncology (NOPHO-AML) and review of the literature

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • 2018-04-30
  • Wiley,2018

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/268595
  • https://gup.ub.gu.se/publication/268595URI
  • https://doi.org/10.1002/gcc.22538DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-147395URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-358123URI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • The t(7;12)(q36;p13) (MNX1/ETV6) is not included in the WHO classification but has been described in up to 30% of acute myeloid leukemia (AML) in children <2 years and associated with a poor prognosis. We present the clinical and cytogenetics characteristics of AML cases with t(7;12)(p36;p13). A literature review identified 35 patients with this translocation, published between 2000 and 2015. Outcome data were available in 22 cases. The NOPHO-AML (Nordic Society for Pediatric Hematology and Oncology) database contained 651 patients with AML from 1993 to 2014 and seven (1.1%) had the translocation. The t(7;12) was only present in patients <2 years of age (median age 6 months) but none was diagnosed as newborn. These patients constituted 4.3% of the patients <2 years of age. There was a strong association with trisomy 19 (literature: 86%, NOPHO: 100%) and +8 (literature: 19%, NOPHO: 14%). Seventeen of 22 patients from the literature with t(7;12) and four of seven patients from the NOPHO database suffered from relapse. The patients with t(7;12) had a 3-year event free survival of 24% (literature) vs. 43% (NOPHO) and a 3-year overall survival of 42% (literature) vs. 100% (NOPHO). None of the NOPHO patients was treated with hematopoietic stem cell transplantation (HSCT) in first complete remission. Relapse was frequent but the salvage rate using HSCT was high. We conclude that t(7;12)(q36;13) is a unique subgroup of childhood AML with presentation before 2 years of age with most cases being associated with +19.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Noren-Nyström, UlrikaDepartment of Pediatrics, Umeå University Hospital, Umeå, Sweden,Umea Univ Hosp, Dept Pediat, Umea, Sweden.(Swepub:umu)kagr0007 (författare)
  • Abrahamsson, Jonas,1954Queen Silvia Childrens Hosp, Dept Pediat, Inst Clin Sci, Gothenburg, Sweden.(Swepub:gu)xabrjo (författare)
  • Ha, S. Y.Queen Mary Hosp, Dept Pediat, Hong Kong, Hong Kong, Peoples R China.;HKPHOSG, Hong Kong, Hong Kong, Peoples R China. (författare)
  • Pronk, C. J.Univ Hosp, Dept Pediat, Lund, Sweden. (författare)
  • Jahnukainen, K.Univ Helsinki, Childrens Hosp, Helsinki, Finland.;Univ Helsinki, Cent Hosp, Helsinki, Finland. (författare)
  • Jonsson, O. G.Landspitalinn, Dept Pediat, Reykjavik, Iceland. (författare)
  • Lausen, B.Univ Copenhagen, Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark. (författare)
  • Palle, Josefine,1964-Uppsala universitet,Barnneurologi/Barnonkologi(Swepub:uu)jopal516 (författare)
  • Zeller, B.Oslo Univ Hosp, Div Pediat & Adolescent Med, Oslo, Norway. (författare)
  • Palmqvist, Lars,1965Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Clin Chem & Transfus Med, Gothenburg, Sweden.(Swepub:gu)xpalla (författare)
  • Hasle, H.Aarhus Univ Hosp Skejby, Dept Pediat, Aarhus, Denmark. (författare)
  • Aarhus Univ Hosp Skejby, Dept Pediat, Aarhus, Denmark.Department of Pediatrics, Umeå University Hospital, Umeå, Sweden (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Genes Chromosomes & Cancer: Wiley57:7, s. 359-3651045-22571098-2264

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