Search: (WFRF:(Lashley T.))
> (2015-2019) >
Molecular biomarker...
Molecular biomarkers of Alzheimer's disease: progress and prospects
-
Lashley, T. (author)
-
Schott, J. M. (author)
-
Weston, P. (author)
-
show more...
-
Murray, C. E. (author)
-
Wellington, H. (author)
-
Keshavan, A. (author)
-
Foti, S. C. (author)
-
Foiani, M. (author)
-
Toombs, J. (author)
-
Rohrer, J. D. (author)
-
Heslegrave, A. (author)
-
- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
show less...
-
(creator_code:org_t)
- 2018-05-08
- 2018
- English.
-
In: Disease Models & Mechanisms. - : The Company of Biologists. - 1754-8403 .- 1754-8411. ; 11:5
- Related links:
-
https://dmm.biologis...
-
show more...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- The neurodegenerative disorder Alzheimer's disease is characterised by the formation of beta-amyloid plaques and neurofibrillary tangles in the brain parenchyma, which cause synapse and neuronal loss. This leads to clinical symptoms, such as progressive memory deficits. Clinically, these pathological changes can be detected in the cerebrospinal fluid and with brain imaging, although reliable blood tests for plaque and tangle pathologies remain to be developed. Plaques and tangles often co-exist with other brain pathologies, including aggregates of transactive response DNA-binding protein 43 and Lewy bodies, but the extent to which these contribute to the severity of Alzheimer's disease is currently unknown. In this 'At a glance' article and poster, we summarise the molecular biornarkers that are being developed to detect Alzheimer's disease and its related pathologies. We also highlight the biornarkers that are currently in clinical use and include a critical appraisal of the challenges associated with applying these biornarkers for diagnostic and prognostic purposes of Alzheimer's disease and related neurodegenerative disorders, also in their prodromal clinical phases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Keyword
- Alzheimer's disease
- Biomarkers
- Cerebrospinal fluid
- Blood
- Plasma
- Serum
- Tau
- Amyloid
- creutzfeldt-jakob-disease
- positron-emission-tomography
- mild cognitive
- impairment
- cerebrospinal-fluid biomarkers
- csf neurofilament proteins
- alpha-synuclein oligomers
- multiple system atrophy
- lewy body dementia
- parkinsons-disease
- neurodegenerative diseases
- Cell Biology
- Pathology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Lashley, T.
-
Schott, J. M.
-
Weston, P.
-
Murray, C. E.
-
Wellington, H.
-
Keshavan, A.
-
show more...
-
Foti, S. C.
-
Foiani, M.
-
Toombs, J.
-
Rohrer, J. D.
-
Heslegrave, A.
-
Zetterberg, Henr ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Cell Biology
- Articles in the publication
-
Disease Models & ...
- By the university
-
University of Gothenburg