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Structural basis fo...
Structural basis for Acinetobacter baumannii biofilm formation
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- Pakharukova, N. (author)
- Univ Turku, Dept Chem, Joint Biotechnol Lab, SF-20500 Turku, Finland
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- Tuittila, M. (author)
- Univ Turku, Dept Chem, Joint Biotechnol Lab, SF-20500 Turku, Finland
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- Paavilainen, S. (author)
- Univ Turku, Dept Chem, Joint Biotechnol Lab, SF-20500 Turku, Finland
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- Malmi, H. (author)
- Univ Turku, Dept Chem, Joint Biotechnol Lab, SF-20500 Turku, Finland
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- Parilova, O. (author)
- Univ Turku, Dept Chem, Joint Biotechnol Lab, SF-20500 Turku, Finland
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- Teneberg, Susann, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,Univ Gothenburg, Sahlgrenska Acad, Dept Med Biochem & Cell Biol, Inst Biomed, S-40530 Gothenburg, Sweden
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- Knight, Stefan D. (author)
- Uppsala universitet,Institutionen för cell- och molekylärbiologi
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- Zavialov, A. V. (author)
- Univ Turku, Dept Chem, Joint Biotechnol Lab, SF-20500 Turku, Finland
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(creator_code:org_t)
- 2018-05-07
- 2018
- English.
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 115:21, s. 5558-5563
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Abstract
Subject headings
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- Acinetobacter baumannii-a leading cause of nosocomial infections-has a remarkable capacity to persist in hospital environments and medical devices due to its ability to form biofilms. Biofilm formation is mediated by Csu pili, assembled via the "archaic" chaperone-usher pathway. The X-ray structure of the CsuC-CsuE chaperone-adhesin preassembly complex reveals the basis for bacterial attachment to abiotic surfaces. CsuE exposes three hydrophobic finger-like loops at the tip of the pilus. Decreasing the hydrophobicity of these abolishes bacterial attachment, suggesting that archaic pili use tip-fingers to detect and bind to hydrophobic cavities in substrates. Antitip antibody completely blocks biofilm formation, presenting a means to prevent the spread of the pathogen. The use of hydrophilic materials instead of hydrophobic plastics in medical devices may represent another simple and cheap solution to reduce pathogen spread. Phylogenetic analysis suggests that the tip-fingers binding mechanism is shared by all archaic pili carrying two-domain adhesins. The use of flexible fingers instead of classical receptor-binding cavities is presumably more advantageous for attachment to structurally variable substrates, such as abiotic surfaces.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- archaic pili
- chaperone-usher pathway
- bacterial adhesion
- biofilm
- Acinetobacter baumannii
- drives fiber formation
- pre-assembly complex
- escherichia-coli
- pilus
- biogenesis
- yersinia-pestis
- psa fimbriae
- adhesin
- fimh
- system
- crystallization
- Science & Technology
- archaic pili
Publication and Content Type
- ref (subject category)
- art (subject category)
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