Expression of ribosomal and actin network proteins and immunochemotherapy resistance in diffuse large B cell lymphoma patients

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Bram Ednersson, SusanneGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine, Department of Pathology,Sahlgrens Univ Hosp, Dept Pathol, Gothenburg, Sweden;Univ Gothenburg, Sahlgrenska Acad, Gothenburg, Sweden (author)

Expression of ribosomal and actin network proteins and immunochemotherapy resistance in diffuse large B cell lymphoma patients

Article/chapterEnglish2018

Publisher, publication year, extent ...

2018-05-16
Wiley,2018

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LIBRIS-ID:oai:gup.ub.gu.se/268731
https://gup.ub.gu.se/publication/268731URI
https://doi.org/10.1111/bjh.15259DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-358164URI

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Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Diffuse large B cell lymphoma (DLBCL) patients with early relapse or refractory disease have a very poor outcome. Immunochemotherapy resistance will probably, also in the era of targeted drugs, remain the major cause of treatment failure. We used proteomic mass spectrometry to analyse the global protein expression of micro-dissected formalin-fixed paraffin-embedded tumour tissues from 97 DLBCL patients: 44 with primary refractory disease or relapse within 1year from diagnosis (REF/REL), and 53 who were progression-free more than 5years after diagnosis (CURED). We identified 2127 proteins: 442 were found in all patients and 102 were differentially expressed. Sixty-five proteins were overexpressed in REF/REL patients, of which 46 were ribosomal proteins (RPs) compared with 2 of the 37 overexpressed proteins in CURED patients (P=76x10(-10)). Twenty of 37 overexpressed proteins in CURED patients were associated with actin regulation, compared with 1 of 65 in REF/REL patients (P=14x10(-9)). Immunohistochemical staining showed higher expression of RPS5 and RPL17 in REF/REL patients while MARCKS-like protein, belonging to the actin network, was more highly expressed in CURED patients. Even though functional studies aimed at individual proteins and protein interactions to evaluate potential clinical effect are needed, our findings suggest new mechanisms behind immunochemotherapy resistance in DLBCL.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Hematologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Hematology hsv//eng
DLBCL
proteomics
immunochemotherapy resistance
ribosomal
actin
rna-polymerase-i
cancer cells
cytoskeletal alterations
therapeutic
strategy
multiple-myeloma
drug-resistance
gastric-cancer
rho
gtpases
doxorubicin
proliferation
Hematology
DLBCL

Added entries (persons, corporate bodies, meetings, titles ...)

Stenson, MartinGothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Kungalvs Hosp, Sect Haematol, Dept Med, Kungalv, Sweden;Univ Gothenburg, Sahlgrenska Acad, Gothenburg, Sweden (author)
Stern, MimmiGothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,South Alvsborg Hosp, Dept Med, Sect Haematol, Boras, Sweden;Univ Gothenburg, Sahlgrenska Acad, Gothenburg, Sweden(Swepub:gu)xstmim (author)
Enblad, GunillaUppsala universitet,Experimentell och klinisk onkologi(Swepub:uu)gunienbl (author)
Fagman, Henrik,1975Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine, Department of Pathology,Sahlgrens Univ Hosp, Dept Pathol, Gothenburg, Sweden;Univ Gothenburg, Sahlgrenska Acad, Gothenburg, Sweden(Swepub:gu)xfagmh (author)
Nilsson-Ehle, Herman,1950Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Sahlgrens Univ Hosp, Sect Haematol & Coagulat, Gothenburg, Sweden;Univ Gothenburg, Sahlgrenska Acad, Gothenburg, Sweden(Swepub:gu)xnilsh (author)
Hasselblom, SverkerDept Res Dev & Educ, Halmstad, Region Halland, Sweden(Swepub:gu)xhasve (author)
Andersson, Per-Ola,1964Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,South Alvsborg Hosp, Dept Med, Sect Haematol, Boras, Sweden;Univ Gothenburg, Sahlgrenska Acad, Gothenburg, Sweden(Swepub:gu)xapert (author)
Göteborgs universitetInstitutionen för biomedicin, avdelningen för patologi (creator_code:org_t)

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In:British Journal of Haematology: Wiley181:6, s. 770-7810007-10481365-2141

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