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Gender-related long...
Gender-related long-term effects in adult rats by perinatal dietary ratio of n-6/n-3 fatty acids.
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- Korotkova, Marina, 1954 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics,University of Gothenburg
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- Gabrielsson, Britt, 1957 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism,University of Gothenburg
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- Holmäng, Agneta, 1959 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Hjärt-kärlinstitutionen,Wallenberg Laboratory,Cardiovascular Institute,University of Gothenburg
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- Larsson, Britt-Mari, 1960 (författare)
- Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute,University of Gothenburg
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- Hanson, Lars Åke, 1934 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk immunologi,Institute of Laboratory Medicine, Dept of Clinical Immunology,University of Gothenburg
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- Strandvik, Birgitta, 1938 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics,University of Gothenburg
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(creator_code:org_t)
- American Physiological Society, 2005
- 2005
- Engelska.
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Ingår i: American journal of physiology. Regulatory, integrative and comparative physiology. - : American Physiological Society. - 0363-6119 .- 1522-1490. ; 288:3
- Relaterad länk:
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://research.cha...
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Abstract
Ämnesord
Stäng
- Epidemiological studies in humans have shown that perinatal nutrition affects health later in life. We have previously shown that the ratio of n-6 to n-3 polyunsaturated fatty acids (PUFA) in the maternal diet affects serum leptin levels and growth of the suckling pups. The aim of the present study was to investigate the long-term effects of various ratios of the dietary n-6 and n-3 PUFA during the perinatal period on serum leptin, insulin, and triacylglycerol, as well as body growth in the adult offspring. During late gestation and throughout lactation, rats were fed an isocaloric diet containing 7 wt% fat, either as linseed oil (n-3 diet), soybean oil (n-6/n-3 diet), or sunflower oil (n-6 diet). At 3 wk of age, the n-6/n-3 PUFA ratios in the serum phospholipids of the offspring were 2.5, 8.3, and 17.5, respectively. After weaning, all pups were given a standard chow. At the 28th postnatal wk, mean body weight and fasting insulin levels were significantly increased in the rats fed the n-6/n-3 diet perinatally compared with the other groups. The systolic blood pressure and serum triacylglycerol levels were only increased in adult male rats of the same group. These data suggest that the balance between n-6 and n-3 PUFA during perinatal development affects several metabolic parameters in adulthood, especially in the male animals.
Nyckelord
- Aging
- blood
- Animals
- Animals
- Newborn
- Cholesterol
- blood
- Diet
- Dose-Response Relationship
- Drug
- Fasting
- blood
- Fatty Acids
- blood
- Fatty Acids
- Omega-3
- administration & dosage
- pharmacology
- Fatty Acids
- Omega-6
- administration & dosage
- pharmacology
- Female
- Fetus
- Insulin
- blood
- Male
- Phospholipids
- blood
- Pregnancy
- Prenatal Exposure Delayed Effects
- Rats
- Rats
- Sprague-Dawley
- Sex Factors
- Time Factors
- Triglycerides
- blood
- pharmacology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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