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S- F-18 THK-5117-PE...
S- F-18 THK-5117-PET and C-11 PIB-PET Imaging in Idiopathic Normal Pressure Hydrocephalus in Relation to Confirmed Amyloid-beta Plaques and Tau in Brain Biopsies
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Leinonen, V. (author)
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Rauramaa, T. (author)
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Johansson, J. (author)
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Bottelbergs, A. (author)
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Tesseur, I. (author)
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van der Ark, P. (author)
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Pemberton, D. (author)
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Koivisto, A. M. (author)
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Jaaskelainen, J. E. (author)
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Hiltunen, M. (author)
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Herukka, S. K. (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Jokinen, P. (author)
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Rokka, J. (author)
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Heliu, S. (author)
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Haaparanta-Solin, M. (author)
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Solin, O. (author)
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Okamura, N. (author)
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Kolb, H. C. (author)
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Rinne, J. O. (author)
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(creator_code:org_t)
- IOS Press, 2018
- 2018
- English.
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In: Journal of Alzheimers Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 64:1, s. 171-179
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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Abstract
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- Background: Detection of pathological tau aggregates could facilitate clinical diagnosis of Alzheimer's disease (AD) and monitor drug effects in clinical trials. S-[F-18] THK-5117 could be a potential tracer to detect pathological tau deposits in brain. However, no previous study have correlated S-[F-18] THK-5117 uptake in PET with brain biopsy verified tau pathology in vivo. Objective: Here we aim to evaluate the association between cerebrospinal fluid (CSF) AD biomarkers, S-[F-18] THK-5117, and [C-11] PIB PET against tau and amyloid lesions in brain biopsy. Methods: Fourteen patients with idiopathic normal pressure hydrocephalus (iNPH) with previous shunt surgery including right frontal cortical brain biopsy and CSF A beta(1-42), total tau, and P-tau(181) measures, underwent brain MRI, [C-11] PIB PET, and S-[F-18] THK-5117 PET imaging. Results: Seven patients had amyloid-beta(A beta, 4G8) plaques, two both A beta and phosphorylated tau (P tau, AT8) and one only P tau in biopsy. As expected, increased brain biopsy A beta was well associated with higher [C-11] PIB uptake in PET. However, S-[F-18] THK-5117 uptake did not show any statistically significant correlation with either brain biopsy P tau or CSF P-tau(181) or total tau. Conclusions: S-[F-18] THK-5117 lacked clear association with neuropathologically verified tau pathology in brain biopsy probably, at least partially, due to off-target binding. Further studies with larger samples of patients with different tau tracers are urgently needed. The detection of simultaneous A beta and tau pathology in iNPH is important since that may indicate poorer and especially shorter response for CSF shunt surgery compared with no pathology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- amyloid-beta
- idiopathic normal pressure hydrocephalus
- neuropathology
- PIB
- positron-emission-tomography
- alzheimers-disease
- follow-up
- biomarkers
- csf
- pathology
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Leinonen, V.
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Rauramaa, T.
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Johansson, J.
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Bottelbergs, A.
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Tesseur, I.
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van der Ark, P.
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show more...
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Pemberton, D.
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Koivisto, A. M.
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Jaaskelainen, J. ...
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Hiltunen, M.
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Herukka, S. K.
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Blennow, Kaj, 19 ...
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Zetterberg, Henr ...
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Jokinen, P.
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Rokka, J.
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Heliu, S.
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Haaparanta-Solin ...
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Solin, O.
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Okamura, N.
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Kolb, H. C.
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Rinne, J. O.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Journal of Alzhe ...
- By the university
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University of Gothenburg