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Primary Stenting of...
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Lindgren, Hans I.V.Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Vaskulära sjukdomar - kliniska studier,Forskargrupper vid Lunds universitet,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Vascular Diseases - Clinical Research,Lund University Research Groups,Helsingborg Hospital
(författare)
Primary Stenting of the Superficial Femoral Artery in Patients with Intermittent Claudication Has Durable Effects on Health-Related Quality of Life at 24 Months: Results of a Randomized Controlled Trial
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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2018-03-08
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Springer Science and Business Media LLC,2018
Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/268749
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https://gup.ub.gu.se/publication/268749URI
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https://doi.org/10.1007/s00270-018-1925-0DOI
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https://lup.lub.lu.se/record/350cbd1b-cbe7-47e1-91cd-34d2964443a6URI
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Ämneskategori:art swepub-publicationtype
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Background Intermittent claudication (IC) is commonly caused by lesions in the superficial femoral artery (SFA), yet invasive treatment is still controversial and longer term patient-reported outcomes are lacking. This prospective randomized trial assessed the 24-month impact of primary stenting with nitinol self-expanding stents compared to best medical treatment (BMT) alone in patients with stable IC due to SFA disease on health-related quality of life (HRQoL). Methods One hundred patients with stable IC due to SFA disease treated with BMT were randomized to either stent (n = 48) or control (n = 52) group. HRQoL assessed by Short Form 36 Health Survey (SF-36) and EuroQoL 5-dimensions (EQ5D) 24 months after treatment were primary outcome measures. Walking Impairment Questionnaire, ankle-brachial index (ABI), and walking distance were secondary outcomes. Results Significantly better SF-36 Physical Component Summary (P = 0.024) and physical domain scores such as Physical Function (P = 0.012), Bodily Pain (P = 0.002), General Health (P = 0.037), and EQ5D (P = 0.010) were reported in intergroup comparison between the stent and the control group. Both ABI (from 0.58 +/- 0.11 to 0.85 +/- 0.18; P < 0.001 in the stent group and from 0.63 +/- 0.17 to 0.69 +/- 0.18; P = 0.036 in the control group) and walking distance (from 170 +/- 90 m to 616 +/- 375 m; P < 0.001 in the stent group and from 209 +/- 111 m to 331 +/- 304 m; P = 0.006 in the control group) improved significantly in intragroup comparisons. Conclusions In patients with IC caused by lesions in the SFA, primary stenting compared to BMT alone was associated with significant improvements in HRQoL, ABI, and walking distance durable up to 24 months of follow-up.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Qvarfordt, PeterHelsingborg Hospital(Swepub:lu)med-pqf
(författare)
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Bergman, StefanLund University,Lunds universitet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Spenshult Research and Development Center,Sahlgrenska Academy(Swepub:lu)med-seb
(författare)
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Gottsäter, AndersLund University,Lunds universitet,Vaskulära sjukdomar - kliniska studier,Forskargrupper vid Lunds universitet,Vascular Diseases - Clinical Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medf-ago
(författare)
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Kliniska Vetenskaper, HelsingborgSektion II
(creator_code:org_t)
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Swedish Endovascular Claudication Stenting Trialists
Sammanhörande titlar
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Ingår i:Cardiovascular and Interventional Radiology: Springer Science and Business Media LLC41:6, s. 872-8810174-15511432-086X
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