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Human skin commensa...
Human skin commensals augment Staphylococcus aureus pathogenesis.
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Boldock, Emma (author)
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Surewaard, Bas G J (author)
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Shamarina, Daria (author)
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- Na, Manli (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Fei, Ying (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Ali, Abukar, 1988 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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Williams, Alexander (author)
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Pollitt, Eric J G (author)
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Szkuta, Piotr (author)
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Morris, Paul (author)
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Prajsnar, Tomasz K (author)
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McCoy, Kathy D (author)
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- Jin, Tao, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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Dockrell, David H (author)
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van Strijp, Jos A G (author)
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Kubes, Paul (author)
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Renshaw, Stephen A (author)
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Foster, Simon J (author)
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(creator_code:org_t)
- 2018-07-16
- 2018
- English.
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In: Nature microbiology. - : Springer Science and Business Media LLC. - 2058-5276. ; 3:8, s. 881-90
- Related links:
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https://www.pure.ed....
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- All bacterial infections occur within a polymicrobial environment, from which a pathogen population emerges to establish disease within a host. Emphasis has been placed on prevention of pathogen dominance by competing microflora acting as probiotics1. Here we show that the virulence of the human pathogen Staphylococcus aureus is augmented by native, polymicrobial, commensal skin flora and individual species acting as 'proinfectious agents'. The outcome is pathogen proliferation, but not commensal. Pathogenesis augmentation can be mediated by particulate cell wall peptidoglycan, reducing the S. aureus infectious dose by over 1,000-fold. This phenomenon occurs using a range of S. aureus strains and infection models and is not mediated by established receptor-mediated pathways including Nod1, Nod2, Myd88 and the NLPR3 inflammasome. During mouse sepsis, augmentation depends on liver-resident macrophages (Kupffer cells) that capture and internalize both the pathogen and the proinfectious agent, leading to reduced production of reactive oxygen species, pathogen survival and subsequent multiple liver abscess formation. The augmented infection model more closely resembles the natural situation and establishes the role of resident environmental microflora in the initiation of disease by an invading pathogen. As the human microflora is ubiquitous2, its role in increasing susceptibility to infection by S. aureus highlights potential strategies for disease prevention.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
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- By the author/editor
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Boldock, Emma
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Surewaard, Bas G ...
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Shamarina, Daria
-
Na, Manli
-
Fei, Ying
-
Ali, Abukar, 198 ...
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show more...
-
Williams, Alexan ...
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Pollitt, Eric J ...
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Szkuta, Piotr
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Morris, Paul
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Prajsnar, Tomasz ...
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McCoy, Kathy D
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Jin, Tao, 1973
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Dockrell, David ...
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van Strijp, Jos ...
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Kubes, Paul
-
Renshaw, Stephen ...
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Foster, Simon J
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show less...
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University of Gothenburg