Biomarkers in cerebrospinal fluid of patients with bipolar disorder versus healthy individuals: A systematic review

• Background: The pathophysiological processes of bipolar disorder (BD) may be detectable by the use of cerebrospinal fluid (CSF) biomarkers. Aim: We aimed for the first time to review studies of CSF biomarkers in patients with BD compared to healthy control individuals (HC). We investigated the effect of diagnosis, age, gender, clinical state, medication, technical characteristics of tests, fasting state and, cognitive function if applicable. Method: We did a systematic review according to the PRISMA Statement based on comprehensive database searches for studies on cerebrospinal biomarkers in patients with bipolar disorder versus HC. Risk of bias was systematically assessed. Results: The search strategy identified 410 studies of which thirty-four fulfilled the inclusion criteria. A total of 117 unique biomarkers were investigated, out of which 11 were evaluated in more than one study. Forty biomarkers showed statistically significant differences between BD and HC in single studies. Only the findings of elevated homovanillic acid and 5-hydroxyindoleacetic acid were replicated across studies. Most studies had a cross sectional design and were influenced by risk of bias mainly due to small sample size, lack of data on mood state at the time of the CSF puncture and not considering potential confounders including age, gender, diagnoses, BMI, life style factors such as smoking, and psychotropic medication. Conclusion: Specific monoamine CSF biomarkers may be related to the pathophysiology of BD. Future studies must aim at increasing the level of evidence by validating the positive findings in prospective studies with stringent methodology. (C) 2018 Elsevier B.V. and ECNP. All rights reserved.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Nyckelord

Cerebrospinal fluid

Bipolar disorder

Biomarker

Systematic review

neurofilament light-chain

major depressive disorder

cell-adhesion

molecule

antipsychotic treatment

psychiatric-patients

csf

acid

immunoreactivity

schizophrenia

metabolites

Neurosciences & Neurology

Pharmacology & Pharmacy

Psychiatry

ncker sj

1968

acta psychiatrica scandinavica

vs

p105

rner rh

1983

american journal of psychiatry

v140

p92

rner rh

1984

american journal of psychiatry

v141

p1533

orge ms

1994

biological psychiatry

v35

p775

orge ms

1994

psychiatry research

v51

p139

rner rh

1982

brain research

v238

p298

Publikations- och innehållstyp

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