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Gene discovery and ...
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Lee, James JUniv Minnesota Twin Cities, Dept Psychol, Minneapolis, MN USA.,University of Minnesota Twin Cities (US)
(author)
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018-07-23
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Springer Science and Business Media LLC,2018
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/269221
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https://gup.ub.gu.se/publication/269221URI
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https://doi.org/10.1038/s41588-018-0147-3DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:138848710URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-364492URI
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https://research.hhs.se/esploro/outputs/journalArticle/Gene-discovery-and-polygenic-prediction-from/991001479407706056URI
Supplementary language notes
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1million individuals and identify 1,271independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11-13% of the variance in educational attainment and 7-10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Wedow, RobbeeUniv Colorado, Dept Sociol, Boulder, CO 80309 USA.;Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA.;Univ Colorado, Inst Behav Sci, Boulder, CO 80309 USA.,University of Colorado
(author)
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Okbay, AysuVrije Univ Amsterdam, Dept Complex Trait Genet, Ctr Neurogen & Cognit Res, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Sch Business & Econ, Dept Econ, Amsterdam, Netherlands.,Vrije Universiteit Amsterdam (NL)
(author)
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Kong, EdwardKarolinska Institutet,Harvard Univ, Dept Econ, Cambridge, MA 02138 USA.,Karolinska Inst, Depnt Med Epidemiol & Biostat, Stockholm, Sweden.,Harvard University (US),Karolinska Institutet (SE)
(author)
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Maghzian, OmeedHarvard Univ, Dept Econ, Cambridge, MA 02138 USA.,Harvard University (US)
(author)
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Zacher, MeghanHarvard Univ, Dept Sociol, Cambridge, MA 02138 USA.,Harvard University (US)
(author)
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Nguyen-Viet, Tuan AnhUniversity of Southern California (US)
(author)
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Bowers, PeterHarvard Univ, Dept Econ, Cambridge, MA 02138 USA.,Harvard University (US)
(author)
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Sidorenko, JuliaUniv Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.;Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.,University of Queensland (AU)
(author)
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Karlsson Linnér, RichardVrije Univ Amsterdam, Dept Complex Trait Genet, Ctr Neurogen & Cognit Res, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Sch Business & Econ, Dept Econ, Amsterdam, Netherlands.,Erasmus University (NL)
(author)
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Fontana, Mark AlanHosp Special Surg, Ctr Adv Value Musculoskeletal Care, 535 E 70th St, New York, NY 10021 USA.,University of Southern California (US)
(author)
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Kundu, TusharUniv Southern Calif, Ctr Econ & Social Res, Los Angeles, CA USA.,University of Southern California (US)
(author)
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Lee, ChanwookHarvard Univ, Dept Econ, Cambridge, MA 02138 USA.,Harvard University (US)
(author)
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Li, HuiHarvard Univ, Dept Econ, Cambridge, MA 02138 USA.,Harvard University (US)
(author)
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Li, RuoxiUniv Southern Calif, Ctr Econ & Social Res, Los Angeles, CA USA.,University of Southern California (US)
(author)
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Royer, RebeccaUniv Southern Calif, Ctr Econ & Social Res, Los Angeles, CA USA.,Univ Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England.,Univ Lausanne, Dept Computat Biol, Lausanne, Switzerland.,University of Cambridge,University of Queensland (AU),University of Southern California (US),Cambridge University (GB)
(author)
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Timshel, Pascal NUniv Copenhagen, Fac Hlth & Med Sci, Sect Metab Genet, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark.;Statens Serum Inst, Dept Epidemiol Res, Copenhagen, Denmark.,Copenhagen University (DK)
(author)
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Walters, Raymond KMassachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA.;MIT & Harvard, Stanley Ctr Psychiat Res, Broad Inst, Cambridge, MA USA.,Broad Institute
(author)
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Willoughby, Emily AUniv Minnesota Twin Cities, Dept Psychol, Minneapolis, MN USA.,University of Minnesota Twin Cities (US)
(author)
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Yengo, LoïcUniv Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.,University of Queensland (AU)
(author)
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Alver, MarisUniv Tartu, Estonian Genome Ctr, Tartu, Estonia.,University of Tartu
(author)
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Bao, YanchunUniv Essex, Inst Social & Econ Res, Colchester, Essex, England.,University of Essex (GB)
(author)
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Clark, David WUniv Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland.,University of Edinburgh
(author)
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Day, Felix R
(author)
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Furlotte, Nicholas A23&Me Inc, Mountain View, CA USA.,23andMe
(author)
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Joshi, Peter KUniv Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland.;Univ Lausanne Hosp, Inst Social & Prevent Med, Lausanne, Switzerland.,University of Edinburgh
(author)
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Kemper, Kathryn EUniv Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.,University of Queensland (AU)
(author)
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Kleinman, Aaron23&Me Inc, Mountain View, CA USA.,23andMe
(author)
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Langenberg, ClaudiaUniv Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England.,Cambridge University (GB)
(author)
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Mägi, ReedikUniv Tartu, Estonian Genome Ctr, Tartu, Estonia.,University of Tartu
(author)
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Trampush, Joey WBrainWorkup LLC, Santa Monica, CA USA.;Univ Southern Calif, Keck Sch Med, Dept Psychiat & Behav Sci, Los Angeles, CA USA.,University of Southern California (US)
(author)
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Verma, Shefali SetiaGeisinger Hlth Syst, Dept Biomed & Translat Informat, Danville, PA USA.,Geisinger Health System
(author)
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Wu, YangUniv Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.,University of Queensland (AU)
(author)
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Lam, MaxInst Mental Hlth, Singapore, Singapore.;Genome Inst, Singapore, Singapore.,Institute of Mental Health
(author)
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Zhao, Jing HuaUniv Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England.,University of Cambridge
(author)
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Zheng, ZhiliUniv Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.;Wenzhou Med Univ, Sch Ophthalmol & Optometry, Eye Hosp, Wenzhou, Peoples R China.,University of Queensland (AU)
(author)
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Boardman, Jason DUniv Colorado, Dept Sociol, Boulder, CO 80309 USA.;Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA.;Univ Colorado, Inst Behav Sci, Boulder, CO 80309 USA.,University of Colorado
(author)
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Campbell, HarryUniv Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland.,University of Edinburgh
(author)
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Freese, JeremyStanford Univ, Dept Sociol, Stanford, CA 94305 USA.,Stanford University (US)
(author)
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Harris, Kathleen MullanUniv North Carolina Chapel Hill, Dept Sociol, Chapel Hill, NC USA.;Univ North Carolina Chapel Hill, Carolina Populat Ctr, Chapel Hill, NC USA.,University of North Carolina
(author)
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Hayward, CarolineUniv Edinburgh, Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland.,University of Edinburgh
(author)
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Herd, PamelaUniv Essex, Inst Social & Econ Res, Colchester, Essex, England.;Univ Wisconsin, La Follette Sch Publ Affairs, Madison, WI USA.,University of Essex (GB)
(author)
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Kumari, MeenaUniv Essex, Inst Social & Econ Res, Colchester, Essex, England.,University of Essex (GB)
(author)
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Lencz, ToddHofstra Northwell Sch Med, Dept Psychiat, Hempstead, NY USA.;Hofstra Northwell Sch Med, Dept Mol Med, Hempstead, NY USA.;Feinstein Inst Med Res, Ctr Psychiat Neurosci, Manhasset, NY USA.;Zucker Hillside Hosp, Psychiat Res, Glen Oaks, CA USA.,Hofstra Northwell School of Medicine
(author)
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Luan, Jian'anUniv Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England.,Cambridge University (GB)
(author)
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Malhotra, Anil KHofstra Northwell Sch Med, Dept Psychiat, Hempstead, NY USA.;Hofstra Northwell Sch Med, Dept Mol Med, Hempstead, NY USA.;Feinstein Inst Med Res, Ctr Psychiat Neurosci, Manhasset, NY USA.;Zucker Hillside Hosp, Psychiat Res, Glen Oaks, CA USA.,Hofstra Northwell School of Medicine
(author)
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Metspalu, AndresUniv Tartu, Estonian Genome Ctr, Tartu, Estonia.;Univ Tartu, Inst Mol & Cell Biol, Tartu, Estonia.,University of Tartu
(author)
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Milani, LiliUniv Tartu, Estonian Genome Ctr, Tartu, Estonia.,University of Tartu
(author)
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Ong, Ken KUniv Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England.,University of Cambridge
(author)
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Perry, John R B
(author)
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Porteous, David JUniv Edinburgh, Inst Genet & Mol Med, Ctr Genom & Expt Med, Edinburgh, Midlothian, Scotland.,University of Edinburgh
(author)
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Ritchie, Marylyn DGeisinger Health System
(author)
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Smart, Melissa CUniv Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland.,University of Edinburgh
(author)
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Smith, Blair HUniv Dundee, Div Populat Hlth Sci, Ninewells Hosp, Dundee, Scotland.;Univ Dundee, Med Sch, Dundee, Scotland.;Univ Dundee, Med Res Inst, Dundee, Scotland.,University of Dundee
(author)
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Tung, Joyce Y23&Me Inc, Mountain View, CA USA.,23andMe
(author)
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Wareham, Nicholas JUniv Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England.,University of Cambridge
(author)
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Wilson, James FUniv Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland.,University of Edinburgh
(author)
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Beauchamp, Jonathan PUniv Toronto, Dept Econ, Toronto, ON, Canada.,University of Toronto (CA)
(author)
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Conley, Dalton CPrinceton Univ, Dept Sociol, Princeton, NJ 08544 USA.,Princeton University (US)
(author)
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Esko, TõnuUniv Tartu, Estonian Genome Ctr, Tartu, Estonia.,University of Tartu
(author)
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Lehrer, Steven FQueens Univ, Sch Policy Studies, Kingston, ON, Canada.;New York Univ Shanghai, Dept Econ, Shanghai, Peoples R China.;Natl Bur Econ Res, Cambridge, MA 02138 USA.,Queen's University
(author)
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Magnusson, Patrik K E
(author)
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Oskarsson, Sven,1971-Uppsala universitet,Statsvetenskapliga institutionen,Uppsala University (SE)(Swepub:uu)sos20331
(author)
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Pers, Tune HUniv Copenhagen, Fac Hlth & Med Sci, Sect Metab Genet, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark.;Statens Serum Inst, Dept Epidemiol Res, Copenhagen, Denmark.,Copenhagen University (DK)
(author)
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Robinson, Matthew R
(author)
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Thom, KevinNYU, Dept Econ, New York, NY 10003 USA.,New York University
(author)
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Watson, ChelseaUniv Southern Calif, Ctr Econ & Social Res, Los Angeles, CA USA.,University of Southern California (US)
(author)
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Chabris, Christopher FGeisinger Hlth Syst, Autism & Dev Med Inst, Lewisburg, PA USA.,Geisinger Health System
(author)
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Meyer, Michelle NGeisinger Hlth Syst, Ctr Translat Bioeth & Hlth Care Policy, Danville, PA USA.,Geisinger Health System
(author)
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Laibson, David IHarvard Univ, Dept Econ, Cambridge, MA 02138 USA.,Harvard University (US)
(author)
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Yang, JianUniv Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.;Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia.,University of Queensland (AU)
(author)
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Johannesson, MagnusStockholm School of Economics,Handelshögskolan i Stockholm(Swepub:hhs)198@hhs.se
(author)
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Koellinger, Philipp DVrije Univ Amsterdam, Dept Complex Trait Genet, Ctr Neurogen & Cognit Res, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Sch Business & Econ, Dept Econ, Amsterdam, Netherlands.;Erasmus Univ, Inst Behav & Biol, Rotterdam, Netherlands.,Vrije Universiteit Amsterdam (NL)
(author)
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Turley, PatrickMassachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA.;MIT & Harvard, Stanley Ctr Psychiat Res, Broad Inst, Cambridge, MA USA.,Massachusetts General Hospital (US)
(author)
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Visscher, Peter MUniv Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.;Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia.,University of Queensland (AU)
(author)
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Benjamin, Daniel JUniv Southern Calif, Ctr Econ & Social Res, Los Angeles, CA USA.;Natl Bur Econ Res, Cambridge, MA 02138 USA.;Univ Southern Calif, Dept Econ, Los Angeles, CA USA.,University of Southern California (US)
(author)
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Cesarini, DavidNYU, Ctr Expt Social Sci, New York, NY USA.,Center for Experimental Social Science
(author)
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Jacobsson, Bo,1960Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xjacbo
(author)
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Univ Minnesota Twin Cities, Dept Psychol, Minneapolis, MN USA.University of Minnesota Twin Cities (US)
(creator_code:org_t)
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23Me Research Team
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Cogent Cognitive Genomics Consorti
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Social Science Genetic Association Consortium
Related titles
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In:Nature genetics: Springer Science and Business Media LLC50:8, s. 1112-11211546-17181061-4036
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Find in a library
To the university's database
- By the author/editor
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Lee, James J
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Wedow, Robbee
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Okbay, Aysu
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Kong, Edward
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Maghzian, Omeed
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Zacher, Meghan
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show more...
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Nguyen-Viet, Tua ...
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Bowers, Peter
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Sidorenko, Julia
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Karlsson Linnér, ...
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Fontana, Mark Al ...
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Kundu, Tushar
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Lee, Chanwook
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Li, Hui
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Li, Ruoxi
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Royer, Rebecca
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Timshel, Pascal ...
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Walters, Raymond ...
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Willoughby, Emil ...
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Yengo, Loïc
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Alver, Maris
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Bao, Yanchun
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Clark, David W
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Day, Felix R
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Furlotte, Nichol ...
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Joshi, Peter K
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Kemper, Kathryn ...
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Kleinman, Aaron
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Langenberg, Clau ...
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Mägi, Reedik
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Trampush, Joey W
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Verma, Shefali S ...
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Wu, Yang
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Lam, Max
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Zhao, Jing Hua
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Zheng, Zhili
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Boardman, Jason ...
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Campbell, Harry
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Freese, Jeremy
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Harris, Kathleen ...
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Hayward, Carolin ...
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Herd, Pamela
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Kumari, Meena
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Lencz, Todd
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Luan, Jian'an
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Malhotra, Anil K
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Metspalu, Andres
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Milani, Lili
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Ong, Ken K
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Perry, John R B
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Porteous, David ...
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Ritchie, Marylyn ...
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Smart, Melissa C
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Smith, Blair H
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Tung, Joyce Y
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Wareham, Nichola ...
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Wilson, James F
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Beauchamp, Jonat ...
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Conley, Dalton C
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Esko, Tõnu
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Lehrer, Steven F
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Magnusson, Patri ...
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Oskarsson, Sven, ...
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Pers, Tune H
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Robinson, Matthe ...
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Thom, Kevin
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Watson, Chelsea
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Chabris, Christo ...
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Meyer, Michelle ...
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Laibson, David I
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Yang, Jian
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Johannesson, Mag ...
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Koellinger, Phil ...
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Turley, Patrick
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Visscher, Peter ...
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Benjamin, Daniel ...
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Cesarini, David
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Jacobsson, Bo, 1 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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NATURAL SCIENCES
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- Articles in the publication
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Nature genetics
- By the university
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University of Gothenburg
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Karolinska Institutet
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Uppsala University
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Stockholm School of Economics