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Lung transplantatio...
Lung transplantation for scleroderma lung disease: An international, multicenter, observational cohort study
- Article/chapterEnglish2018
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Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/269249
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https://gup.ub.gu.se/publication/269249URI
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https://doi.org/10.1016/j.healun.2018.03.003DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND: Due to its multisystemic nature, scleroderma is considered a relative contraindication to lung transplantation at many centers. However, recent studies suggest similar post-transplant outcomes in patients with scleroderma compared to those with other causes of interstitial lung disease (ILD). Furthermore, it remains unknown whether scleroderma-associated pulmonary arterial hypertension (PAH) influences post-transplant outcomes. Our objective in this study was to assess the indications, survival, and prognostic factors of lung or heart lung transplantation for scleroderma lung disease. METHODS: We retrospectively reviewed the data of 90 patients with scleroderma who underwent lung or heart lung transplantation between 1993 and 2016 at 14 European centers. International criteria were used to diagnose scleroderma. Pulmonary hypertension (PH) was diagnosed during right heart catheterization based on international guidelines. RESULTS: Survival rates after 1, 3, and 5 years were 81%, 68%, and 61%, respectively. By univariate analysis, borderline-significant associations with poorer survival were found for female gender (hazard ratio 2.11; 95% confidence interval [CI] 0.99 to 4.50; p = 0.05) and PAH as the reason for transplantation (hazard ratio 1.90; 95% CI 0.96 to 3.92; p = 0.06). When both these factors were present in combination, the risk of death was 3-fold that in males without PAH. The clinical and histologic presentation resembled veno-occlusive disease in 75% of patients with PAH. CONCLUSIONS: Post-transplant survival rates and freedom from chronic lung allograft dysfunction in patients with scleroderma were similar to those in patients with other reasons for lung transplantation. Female sex and PAH in combination was associated with lower survival. (C) 2018 International Society for Heart and Lung Transplantation. All rights reserved.
Subject headings and genre
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MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
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MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
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female
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lung transplantation
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pulmonary arterial hypertension
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pulmonary hypertension
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pulmonary arterial-hypertension
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single-center experience
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systemic-sclerosis
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venoocclusive disease
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survival
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outcomes
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classification
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heart
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population
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capacity
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Cardiovascular System & Cardiology
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Respiratory System
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Surgery
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Transplantation
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een vd
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1994
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arthritis and rheumatism
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v37
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p1283
Added entries (persons, corporate bodies, meetings, titles ...)
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Tudorache, I.
(author)
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Magnusson, JesperGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
(author)
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Savale, L.
(author)
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Brugiere, O.
(author)
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Douvry, B.
(author)
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Reynaud-Gaubert, M.
(author)
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Claustre, J.
(author)
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Le Borgne, A.
(author)
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Holm, A. M.
(author)
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Schultz, H. H.
(author)
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Knoop, C.
(author)
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Godinas, L.
(author)
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Fisher, A. J.
(author)
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Hirschi, S.
(author)
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Gottlieb, J.
(author)
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Le Pavec, J.
(author)
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Göteborgs universitetInstitutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition
(creator_code:org_t)
Related titles
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In:Journal of Heart and Lung Transplantation: Elsevier BV37:7, s. 903-9111053-2498
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Pradere, P.
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Tudorache, I.
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Magnusson, Jespe ...
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Savale, L.
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Brugiere, O.
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Douvry, B.
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Reynaud-Gaubert, ...
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Claustre, J.
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Le Borgne, A.
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Holm, A. M.
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Schultz, H. H.
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Knoop, C.
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Godinas, L.
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Fisher, A. J.
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Hirschi, S.
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Gottlieb, J.
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Le Pavec, J.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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University of Gothenburg