Neurofilament relates to white matter microstructure in older adults.

Cerebrospinal fluid (CSF) neurofilament light (NFL) is a protein biomarker of axonal injury. To study whether NFL is associated with diffusion tensor imaging (DTI) measurements of white matter (WM) microstructure, Vanderbilt Memory & Aging Project participants with normal cognition (n= 77), early mild cognitive impairment (n= 15), and MCI (n= 55) underwent lumbar puncture to obtain CSF and 3T brain MRI. Voxel-wise analyses cross-sectionally related NFL to DTI metrics, adjusting for demographic and vascular risk factors. Increased NFL correlated with multiple DTI metrics (p-values < 0.05). An NFL× diagnosis interaction (excluding early mild cognitive impairment) on WM microstructure (p-values < 0.05) was detected, with associations strongest among MCI. Multiple NFL× CSF biomarker interactions were detected. Associations between NFL and worse WM metrics were strongest among amyloid-β42-negative, tau-positive, and suspected nonamyloid pathology participants. Findings suggest increased NFL, a biomarker of axonal injury, is correlated with compromised WM microstructure. Results highlight the role of elevated NFL in predicting WM damage in cognitively impaired older adults who are amyloid-negative, tau-positive, or meet suspected nonamyloid pathology criteria.

Hohman, Timothy J (author)
Badami, Faizan S (author)
Pechman, Kimberly R (author)
Osborn, Katie E (author)
Acosta, Lealani Mae Y (author)
Bell, Susan P (author)
Babicz, Michelle A (author)
Gifford, Katherine A (author)
Anderson, Adam W (author)
Goldstein, Lee E (author)
Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka (author)
Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe (author)
Jefferson, Angela L (author)
Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)

By the author/editor: Moore, Elizabeth ...; Hohman, Timothy ...; Badami, Faizan S; Pechman, Kimberl ...; Osborn, Katie E; Acosta, Lealani ...; show more...; Bell, Susan P; Babicz, Michelle ...; Gifford, Katheri ...; Anderson, Adam W; Goldstein, Lee E; Blennow, Kaj, 19 ...; Zetterberg, Henr ...; Jefferson, Angel ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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