Gut microbiota, metabolism and psychopathology: A critical review and novel perspectives

• Psychiatric disorders are often associated with metabolic comorbidities. However, the mechanisms through which metabolic and psychiatric disorders are connected remain unclear. Pre-clinical studies in rodents indicate that the bidirectional signaling between the intestine and the brain, the so-called microbiome-gut-brain axis, plays an important role in the regulation of both metabolism and behavior. The gut microbiome produces a vast number of metabolites that may be transported into the host and play a part in homeostatic control of metabolism as well as brain function. In addition to short chain fatty acids, many of these metabolites have been identified in recent years. To what extent both microbiota and their products control human metabolism and behavior is a subject of intense investigation. In this review, we will discuss the most recent findings concerning alterations in the gut microbiota as a possible pathophysiological factor for the co-occurrence of metabolic comorbidities in psychiatric disorders.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)

Nyckelord

Gut-brain axis

bile acid

psychiatry

metabolic syndrome

fecal transplantation

germ free

major depressive disorder

autistic spectrum disorders

irritable-bowel-syndrome

time-series analysis

chain fatty-acids

intestinal microbiota

insulin sensitivity

fecal microbiota

tryptophan-metabolism

network perspective

Medical Laboratory Technology

ates of america

v108

p3047

ates of america

v106

p3698

Publikations- och innehållstyp

ref (ämneskategori)

for (ämneskategori)