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Autoradiography and...
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Hemmingsson, Jens,1986Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiofysik,Institute of Clinical Sciences, Department of Radiation Physics,Department of Radiation Physics, The Sahlgrenska Academy, Sahlgrenska University Hospital, Gothenburg, Sweden
(author)
Autoradiography and biopsy measurements of a resected hepatocellular carcinoma treated with 90 yttrium radioembolization demonstrate large absorbed dose heterogeneities
- Article/chapterEnglish2018
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LIBRIS-ID:oai:gup.ub.gu.se/269808
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https://gup.ub.gu.se/publication/269808URI
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https://doi.org/10.1016/j.adro.2018.04.008DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-155843URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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© 2018 The Authors Purpose: Radioembolization is an alternative palliative treatment for hepatocellular carcinoma. Here, we examine the uptake differences between tumor tissue phenotypes and present a cross-section of the absorbed dose throughout a liver tissue specimen. Methods and materials: A patient with hepatocellular carcinoma was treated with90Y radioembolization followed by liver tissue resection. Gamma camera images and autoradiographs were collected and biopsy tissue samples were analyzed using a gamma well counter and light microscopy. Results: An analysis of 25 punched biopsy tissue samples identified 4 tissue regions: Normal tissue, viable tumor tissue with and without infarcted areas, and tumor areas with postnecrotic scar tissue. Autoradiography and biopsy tissue sample measurements showed large dose differences between viable and postnecrotic tumor tissue (159 Gy vs 23 Gy). Conclusions: Radioembolization of 90 yttrium with resin microspheres produces heterogeneous-absorbed dose distributions in the treatment of unifocal hepatic malignancies that could not be accurately determined with current gamma camera imaging techniques.
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Högberg, Jonas,1976Region Östergötland, Medicinsk strålningsfysik(Swepub:gu)xhojon
(author)
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Mölne, Johan,1958Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine, Department of Pathology,Department of Pathology, The Sahlgrenska Academy, Sahlgrenska University Hospital, Gothenburg, Sweden(Swepub:gu)xmolnj
(author)
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Svensson, JohannaGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology,Department of Oncology, The Sahlgrenska Academy, Sahlgrenska University Hospital, Gothenburg, Sweden(Swepub:gu)xsvjod
(author)
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Gjertsson, Peter,1961Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Department of Clinical Physiology, The Sahlgrenska Academy, Sahlgrenska University Hospital, Gothenburg, Sweden(Swepub:gu)xgjepe
(author)
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Rizell, Magnus,1963Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery,Department of Surgery, The Sahlgrenska Academy, Sahlgrenska University Hospital, Gothenburg, Sweden(Swepub:gu)xrizma
(author)
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Henrikson, OlofGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology,Department of Radiology, The Sahlgrenska Academy, Sahlgrenska University Hospital, Gothenburg, Sweden
(author)
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Bernhardt, Peter,1966Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiofysik,Institute of Clinical Sciences, Department of Radiation Physics,Department of Radiation Physics, The Sahlgrenska Academy, Sahlgrenska University Hospital, Gothenburg, Sweden(Swepub:gu)xbernp
(author)
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Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för radiofysik
(creator_code:org_t)
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In:Advances in Radiation Oncology: Elsevier BV3:3, s. 439-4462452-1094
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