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Smoking, disease ch...
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Olsson, PeterLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital
(författare)
Smoking, disease characteristics and serum cytokine levels in patients with primary Sjogren's syndrome
- Artikel/kapitelEngelska2018
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2018-05-30
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Springer Science and Business Media LLC,2018
Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/269843
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https://gup.ub.gu.se/publication/269843URI
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https://doi.org/10.1007/s00296-018-4063-8DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-150246URI
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https://lup.lub.lu.se/record/432c17ed-0b99-4117-81f6-c9d199d88a1aURI
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Funding Agencies|Sjogrens syndrome foundation; ALF-Skane; Kocks Foundation; Skane University Hospital; Swedish Rheumatism Association
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Smoking affects several disease processes. Epidemiological studies have previously found a negative association between primary Sjogren's syndrome (pSS) and smoking. The aim of this study was to examine whether markers of disease activity and cytokine expression in pSS patients differ between ever and never smokers. Fifty-one consecutive pSS patients and 33 population controls were included in the study. Clinical and standard laboratory parameters were registered. Serum cytokines (IL-1 beta, IL-2, IL-3, IL-4, IL-6, IL-8, IL-10, IL-12, IL-17, IL-18, IL-33, IFN-alpha, IFN-gamma, TNF-alpha, EGF, BAFF, Fas-ligand, RANTES, TGF-beta 1) were assessed. A positive lip biopsy was less prevalent among ever smoking patients compared to never smokers (81 vs 100%; p = 0.03). However, except for TNF-alpha, which was higher in ever smokers, no differences in cytokine levels were found when comparing ever and never smoking pSS patients. Furthermore, no significant differences were found between ever and never smoking patients in the ESSDAI total score, IgG levels, or complement levels. However, IL-6, IL-12, IL-17 and IL-18 were significantly increased in pSS patients compared to controls. In this study, a negative association between ever smoking and positive lip biopsy was found, confirming previous reports. Expected differences in cytokine levels compared to controls were noted, but no major differences were found between ever and never smoking pSS patients. Taking into account the negative association between pSS diagnosis and smoking in epidemiological studies, possible explanations include a local effect of smoking on salivary glands rather than systemic effects by cigarette smoke.
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Skogstrand, K.Statens Serum Inst, Denmark,Danish Serum Institute, Copenhagen
(författare)
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Nilsson, AnnaLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Linköping University Hospital(Swepub:lu)med-a1n
(författare)
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Turesson, CarlLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-ctn
(författare)
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Jacobsson, Lennart T. H.,1954Lund University,Lunds universitet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Lund Univ, Sweden; Univ Gothenburg, Sweden,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Sahlgrenska Academy(Swepub:lu)orto-lja
(författare)
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Theander, ElkeLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Janssen-Cilag AB(Swepub:lu)medf-eth
(författare)
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Houen, G.Statens Serum Inst, Denmark,Danish Serum Institute, Copenhagen
(författare)
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Mandl, ThomasLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medf-tma
(författare)
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Internmedicin - epidemiologiForskargrupper vid Lunds universitet
(creator_code:org_t)
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Ingår i:Rheumatology International: Springer Science and Business Media LLC38:8, s. 1503-15100172-81721437-160X
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