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Spleen development ...
Spleen development is modulated by neonatal gut microbiota
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Rosado, M. M. (author)
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- Aranburu, Alaitz (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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Scarsella, M. (author)
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Cascioli, S. (author)
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Giorda, E. (author)
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Del Chierico, F. (author)
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Mortera, S. L. (author)
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Mortari, E. P. (author)
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Petrini, S. (author)
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Putignani, L. (author)
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Carsetti, R. (author)
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English.
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In: Immunology Letters. - : Elsevier BV. - 0165-2478. ; 199, s. 1-15
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- The full development of the mammalian immune system occurs after birth upon exposure to non self-antigens. The gut is the first site of bacterial colonization where it is crucial to create the appropriate microenvironment able to balance effector or tolerogenic responses to external stimuli. It is a well-established fact that at mucosal sites bacteria play a key role in developing the immune system but we ignore how colonising bacteria impact the maturation of the spleen. Here we addressed this issue. Taking advantage of the fact that milk SIgA regulates bacterial colonization of the newborn intestine, we generated immunocompetent mice born either from IgA pro-efficient or IgA deficient females. Having demonstrated that SIgA in maternal milk modulates neonatal gut microbiota by promoting an increased diversity of the colonizing species we also found that immunocompetent pups, not exposed to milk SIgA, fail to properly develop the FDC network and primary follicles in the spleen compromising the response to T-dependent antigens. The presence of a less diverse microbiota with a higher representation of pathogenic species leads to a fast replenishment of the marginal zone and the IgM plasma cell compartment of the spleen as well as IgA plasma cells in the gut. © 2018 European Federation of Immunological Societies
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- B cell maturation
- Gut microbiota
- Secretory IgA
- Spleen
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Rosado, M. M.
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Aranburu, Alaitz
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Scarsella, M.
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Cascioli, S.
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Giorda, E.
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Del Chierico, F.
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show more...
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Mortera, S. L.
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Mortari, E. P.
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Petrini, S.
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Putignani, L.
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Carsetti, R.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Immunology Lette ...
- By the university
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University of Gothenburg