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Ancient human parvo...
Ancient human parvovirus B19 in Eurasia reveals its long-term association with humans
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- Muhlemann, B. (author)
- Univ Cambridge, Dept Zool, Ctr Pathogen Evolut, Cambridge CB2 3EJ, England
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- Margaryan, A. (author)
- Univ Copenhagen, Nat Hist Museum Denmark, Ctr GeoGenet, DK-1350 Copenhagen K, Denmark;Natl Acad Sci, Inst Mol Biol, Yerevan 0014, Armenia,Erasmus MC, Dept Virosci, NL-3015 CN Rotterdam, Netherlands
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- Damgaard, P. D. (author)
- Univ Copenhagen, Nat Hist Museum Denmark, Ctr GeoGenet, DK-1350 Copenhagen K, Denmark
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- Allentoft, M. E. (author)
- Univ Copenhagen, Nat Hist Museum Denmark, Ctr GeoGenet, DK-1350 Copenhagen K, Denmark,Polish Acad Sci, Museum & Inst Zool, PL-00679 Warsaw, Poland
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- Vinner, L. (author)
- Univ Copenhagen, Nat Hist Museum Denmark, Ctr GeoGenet, DK-1350 Copenhagen K, Denmark
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- Hansen, A. J. (author)
- Univ Copenhagen, Nat Hist Museum Denmark, Ctr GeoGenet, DK-1350 Copenhagen K, Denmark,Univ Edinburgh, Sch GeoSci, Edinburgh EH8 9XP, Midlothian, Scotland;Natl Museum Denmark, DK-1220 Copenhagen, Denmark
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- Weber, A. (author)
- Univ Alberta, Dept Anthropol, Edmonton, AB T6G 2H4, Canada
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- Bazaliiskii, V. I. (author)
- Irkutsk State Univ, Dept Hist, Irkutsk 664003, Russia
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Molak, M. (author)
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Arneborg, J. (author)
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- Bogdanowicz, W. (author)
- Polish Acad Sci, Museum & Inst Zool, PL-00679 Warsaw, Poland
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- Falys, C. (author)
- TVAS, Reading RG1 5NR, Berks, England
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- Sablin, M. (author)
- Russian Acad Sci, Zool Inst, Lab Theriol, St Petersburg 199034, Russia
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- Smrcka, V. (author)
- Charles Univ Prague, Fac Med 1, Inst Hist Med & Foreign Languages, Prague 12108, Czech Republic
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- Sten, Sabine, 1956- (author)
- Uppsala universitet,Arkeologi
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- Tashbaeva, K. (author)
- Natl Acad Sci, Inst Hist & Cultural Heritage, Bishkek 720001, Kyrgyzstan
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- Lynnerup, N. (author)
- Univ Copenhagen, Dept Forens Med, DK-2100 Copenhagen, Denmark
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- Sikora, M. (author)
- Univ Copenhagen, Nat Hist Museum Denmark, Ctr GeoGenet, DK-1350 Copenhagen K, Denmark
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- Smith, D. J. (author)
- Univ Cambridge, Dept Zool, Ctr Pathogen Evolut, Cambridge CB2 3EJ, England
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Fouchier, R. A. M. (author)
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- Drosten, C. (author)
- Charite Univ Med Berlin, Inst Virol, D-10117 Berlin, Germany
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- Sjögren, Karl-Göran, 1949 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för historiska studier,Department of Historical Studies,Univ Gothenburg, Dept Hist Studies, S-41261 Gothenburg, Sweden
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- Kristiansen, Kristian, 1948 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för historiska studier,Department of Historical Studies,Univ Gothenburg, Dept Hist Studies, S-41261 Gothenburg, Sweden
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- Willerslev, E. (author)
- Univ Copenhagen, Nat Hist Museum Denmark, Ctr GeoGenet, DK-1350 Copenhagen K, Denmark;Univ Cambridge, Dept Zool, Cambridge GeoGenet Grp, Cambridge CB2 3EJ, England;Wellcome Trust Sanger Inst, Human Genet, Hinxton CB10 1SA, England
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- Jones, T. C. (author)
- Univ Cambridge, Dept Zool, Ctr Pathogen Evolut, Cambridge CB2 3EJ, England;Charite Univ Med Berlin, Inst Virol, D-10117 Berlin, Germany
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(creator_code:org_t)
- 2018-07-02
- 2018
- English.
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 115:29, s. 7557-7562
- Related links:
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https://www.pnas.org...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Human parvovirus B19 (B19V) is a ubiquitous human pathogen associated with a number of conditions, such as fifth disease in children and arthritis and arthralgias in adults. B19V is thought to evolve exceptionally rapidly among DNA viruses, with substitution rates previously estimated to be closer to those typical of RNA viruses. On the basis of genetic sequences up to similar to 70 years of age, the most recent common ancestor of all B19V has been dated to the early 1800s, and it has been suggested that genotype 1, the most common B19V genotype, only started circulating in the 1960s. Here we present 10 genomes (63.9-99.7% genome coverage) of B19V from dental and skeletal remains of individuals who lived in Eurasia and Greenland from similar to 0.5 to similar to 6.9 thousand years ago (kya). In a phylogenetic analysis, five of the ancient B19V sequences fall within or basal to the modern genotype 1, and five fall basal to genotype 2, showing a long-term association of B19V with humans. The most recent common ancestor of all B19V is placed similar to 12.6 kya, and we find a substitution rate that is an order of magnitude lower than inferred previously. Further, we are able to date the recombination event between genotypes 1 and 3 that formed genotype 2 to similar to 5.0-6.8 kya. This study emphasizes the importance of ancient viral sequences for our understanding of virus evolution and phylogenetics.
Subject headings
- HUMANIORA -- Historia och arkeologi -- Historia (hsv//swe)
- HUMANITIES -- History and Archaeology -- History (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- parvovirus B19
- ancient DNA
- virus evolution
- paleo virology
- virology
- genetic diversity
- dna
- persistence
- identification
- erythrovirus
- evolution
- viruses
- genomes
- genotype-1
- history
- Science & Technology - Other Topics
- apman ms
- 1995
- structure
- v3
- p151
- parvovirus B19
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Muhlemann, B.
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Margaryan, A.
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Damgaard, P. D.
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Allentoft, M. E.
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Vinner, L.
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Hansen, A. J.
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show more...
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Weber, A.
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Bazaliiskii, V. ...
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Molak, M.
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Arneborg, J.
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Bogdanowicz, W.
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Falys, C.
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Sablin, M.
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Smrcka, V.
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Sten, Sabine, 19 ...
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Tashbaeva, K.
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Lynnerup, N.
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Sikora, M.
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Smith, D. J.
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Fouchier, R. A. ...
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Drosten, C.
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Sjögren, Karl-Gö ...
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Kristiansen, Kri ...
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Willerslev, E.
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Jones, T. C.
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- About the subject
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- HUMANITIES
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HUMANITIES
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and History and Arch ...
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and History
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Proceedings of t ...
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Proceedings of t ...
- By the university
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University of Gothenburg
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Uppsala University