High burden of Aspergillus fumigatus infection among chronic respiratory diseases

Aspergillus fumigatus (AF) is a ubiquitous fungus in our environment and causes severe airway disorders. Chronic respiratory diseases (CRDs) are a series of chronic airway and lung diseases. Although both are chronic disorders, however, the relationships between AF and CRDs are still unclear. Therefore, we examined 104 Aspergillus species (spp.) isolated samples in our hospital during three consecutive years to further elucidate the relationships between Aspergillus spp. and CRDs. Based on sample isolates, we then grouped these into two groups, AF and non-AF, to retrospectively analyse the clinical features and to clarify the relationships between AF and CRDs. Importantly, the manifestation of CRD was more frequent in the AF group than in the non-AF group (p = 0.035). Among CRDs, lung fibrosis was more evident in the AF group (p = 0.025). Moreover, diabetes mellitus was tended to be evident in AF group than non-AF group (p = 0.035). In conclusion, CRDs, especially lung fibrosis, were highly prevalent in AF group than non-AF group.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Lungmedicin och allergi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Respiratory Medicine and Allergy hsv//eng
Aspergillus fumigatus
chronic respiratory disease
lung fibrosis
COPD
asthma
idiopathic pulmonary-fibrosis
lung-disease
pathogenesis
microbiome
diagnosis

Homma, T. (författare)
Suzuki, ShintaroGothenburg University,Göteborgs universitet,Krefting Research Centre (författare)
Takuma, T. (författare)
Tanaka, A. (författare)
Yokoe, T. (författare)
Ohnishi, T. (författare)
Niki, Y. (författare)
Sagara, H. (författare)
Göteborgs universitetKrefting Research Centre (creator_code:org_t)

Ingår i:Chronic Respiratory Disease: SAGE Publications15:3, s. 279-2851479-97231479-9731

Av författaren/redakt...: Fukuda, Y.; Homma, T.; Suzuki, Shintaro; Takuma, T.; Tanaka, A.; Yokoe, T.; visa fler...; Ohnishi, T.; Niki, Y.; Sagara, H.; visa färre...

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