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Direct detection of...
Direct detection of Exophiala and Scedosporium species in sputa of patients with cystic fibrosis
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Chen, M. (author)
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- Kondori, Nahid, 1967 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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Deng, S. W. (author)
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van den Ende, Ahgg (author)
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Lackner, M. (author)
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Liao, W. Q. (author)
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de Hoog, G. S. (author)
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(creator_code:org_t)
- 2017-12-08
- 2018
- English.
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In: Medical Mycology. - : Oxford University Press (OUP). - 1369-3786 .- 1460-2709. ; 56:6, s. 695-702
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https://academic.oup...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Detection of species of Exophiala and Scedosporium in the respiratory tracts of cystic fibrosis (CF) patients remains controversial because of highly variable results. The results of our study suggested a significantly higher prevalence and more complex colonization than previously estimated. Approximately 17% (27/162) of clinical sputum samples were found to be positive for Exophiala dermatitidis and 30% (49/162) were positive for Scedosporium apiospermum / S. boydii species complex determined by reverse line blot (RLB) hybridization. In contrast, only 14.2% (23/162) and 1.2% ( 2 / 1 62) of clinical sputa were positive for E. dermatitidis and S. apiospermum / S. boydii species complex when tested by culture, respectively. Molecular detection methods, such as loop-mediated isothermal amplification (LAMP) or reverse line blot (RLB) hybridization, have the potential to become powerful alternatives to selective culture, providing a more realistic understanding on the prevalence of E. dermatitidis and S. apiospermum / S. boydii species complex in the respiratory tract of CF patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- Exophiala dermatitidis
- Scedosporium
- cystic fibrosis
- sputum
- molecular epidemiology
- filamentous fungi
- culture-medium
- dermatitidis
- apiospermum
- prevalence
- pseudallescheria
- amplification
- infection
- complex
- Infectious Diseases
- Mycology
- Veterinary Sciences
Publication and Content Type
- ref (subject category)
- art (subject category)
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