Search: (WFRF:(Björnson Elias)) srt2:(2018) >
Characterization of...
Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome
-
- Lovric, Alen (author)
- KTH,Science for Life Laboratory, SciLifeLab
-
- Graner, M. (author)
- Helsinki University Central Hospital,Univ Helsinki, Heart & Lung Ctr, Div Cardiol, Cent Hosp, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.
-
- Björnson, Elias, 1988 (author)
- Chalmers tekniska högskola,Chalmers University of Technology,Chalmers Univ Technol, Dept Biol & Biol Engn, Gothenburg, Sweden.;Univ Gothenburg, Wallenberg Lab, Dept Mol & Clin Med, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Gothenburg, Sweden.
-
show more...
-
- Arif, Muhammad (author)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi
-
- Benfeitas, Rui (author)
- KTH,Science for Life Laboratory, SciLifeLab
-
- Nyman, K. (author)
- Helsinki University Central Hospital,Univ Helsinki, Helsinki, Finland.;Univ Helsinki, HUS Med Imaging Ctr, Dept Radiol, Cent Hosp, Helsinki, Finland.
-
- Ståhlman, Marcus, 1975 (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Wallenberg Lab, Dept Mol & Clin Med, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Gothenburg, Sweden.
-
- Pentikainen, M. O. (author)
- Helsinki University Central Hospital,Univ Helsinki, Heart & Lung Ctr, Div Cardiol, Cent Hosp, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.
-
- Lundborn, J. (author)
- Helsinki University Central Hospital,Univ Helsinki, Helsinki, Finland.;Univ Helsinki, HUS Med Imaging Ctr, Dept Radiol, Cent Hosp, Helsinki, Finland.
-
- Hakkarainen, A. (author)
- Helsinki University Central Hospital,Univ Helsinki, Helsinki, Finland.;Univ Helsinki, HUS Med Imaging Ctr, Dept Radiol, Cent Hosp, Helsinki, Finland.
-
- Siren, R. (author)
- Univ Helsinki, Helsinki, Finland.;Hlth Care Ctr City Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.
-
- Nieminen, M. S. (author)
- Helsinki University Central Hospital,Univ Helsinki, Heart & Lung Ctr, Div Cardiol, Cent Hosp, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.
-
- Lundborns, N. (author)
- Univ Helsinki, Helsinki, Finland.;Univ Helsinki, HUS Med Imaging Ctr, Dept Radiol, Cent Hosp, Helsinki, Finland.
-
- Lauermas, K. (author)
- Helsinki University Central Hospital,Univ Helsinki, Helsinki, Finland.;Univ Helsinki, HUS Med Imaging Ctr, Dept Radiol, Cent Hosp, Helsinki, Finland.
-
- Taskinen, M. R. (author)
- Helsinki University Central Hospital,Univ Helsinki, Heart & Lung Ctr, Div Cardiol, Cent Hosp, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.
-
- Mardinoglu, Adil, 1982 (author)
- KTH,Science for Life Laboratory, SciLifeLab
-
- Borén, Jan, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory,Univ Gothenburg, Wallenberg Lab, Dept Mol & Clin Med, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Gothenburg, Sweden.
-
- Lundbom, N. (author)
- Helsinki University Central Hospital
-
show less...
-
(creator_code:org_t)
- 2018-09-21
- 2018
- English.
-
In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 8
- Related links:
-
https://gup.ub.gu.se... (primary) (free)
-
show more...
-
https://www.nature.c...
-
https://research.cha... (primary) (free)
-
https://doi.org/10.1...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
https://research.cha...
-
https://research.cha...
-
https://research.cha...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Non-alcoholic fatty liver disease (NAFLD) is recognized as a liver manifestation of metabolic syndrome, accompanied with excessive fat accumulation in the liver and other vital organs. Ectopic fat accumulation was previously associated with negative effects at the systemic and local level in the human body. Thus, we aimed to identify and assess the predictive capability of novel potential metabolic biomarkers for ectopic fat depots in non-diabetic men with NAFLD, using the inflammation-associated proteome, lipidome and metabolome. Myocardial and hepatic triglycerides were measured with magnetic spectroscopy while function of left ventricle, pericardial and epicardial fat, subcutaneous and visceral adipose tissue were measured with magnetic resonance imaging. Measured ectopic fat depots were profiled and predicted using a Random Forest algorithm, and by estimating the Area Under the Receiver Operating Characteristic curves. We have identified distinct metabolic signatures of fat depots in the liver (TAG50:1, glutamate, diSM18:0 and CE20:3), pericardium (N-palmitoyl-sphinganine, HGF, diSM18:0, glutamate, and TNFSF14), epicardium (sphingomyelin, CE20:3, PC38:3 and TNFSF14), and myocardium (CE20:3, LAPTGF-beta 1, glutamate and glucose). Our analyses highlighted non-invasive biomarkers that accurately predict ectopic fat depots, and reflect their distinct metabolic signatures in subjects with NAFLD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- growth-factor 21
- myocardial triglyceride content
- type-2
- diabetes-mellitus
- liver-disease
- insulin-resistance
- cardiovascular-disease
- mass-spectrometry
- adipose-tissue
- cardiac
- steatosis
- skeletal-muscle
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Lovric, Alen
-
Graner, M.
-
Björnson, Elias, ...
-
Arif, Muhammad
-
Benfeitas, Rui
-
Nyman, K.
-
show more...
-
Ståhlman, Marcus ...
-
Pentikainen, M. ...
-
Lundborn, J.
-
Hakkarainen, A.
-
Siren, R.
-
Nieminen, M. S.
-
Lundborns, N.
-
Lauermas, K.
-
Taskinen, M. R.
-
Mardinoglu, Adil ...
-
Borén, Jan, 1963
-
Lundbom, N.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Other Clinical M ...
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Nutrition and Di ...
- Articles in the publication
-
Scientific Repor ...
- By the university
-
University of Gothenburg
-
Chalmers University of Technology
-
Royal Institute of Technology