Evaluation of changes in Bone Scan Index at different acquisition time-points in bone scintigraphy

• Bone Scan Index (BSI) is a validated imaging biomarker to objectively assess tumour burden in bone in patients with prostate cancer, and can be used to monitor treatment response. It is not known if BSI is significantly altered when images are acquired at a time difference of 1h. The aim of this study was to investigate if automatic calculation of BSI is affected when images are acquired 1hour apart, after approximately 3 and 4h. We prospectively studied patients with prostate cancer who were referred for bone scintigraphy according to clinical routine. The patients performed a whole-body bone scan at approximately 3h after injection of radiolabelled bisphosphonate and a second 1h after the first. BSI values for each bone scintigraphy were obtained using EXINI bone(BSI) software. A total of 25 patients were included. Median BSI for the first acquisition was 005 (range 0-1193) and for the second acquisition 021 (range 0-1306). There was a statistically significant increase in BSI at the second image acquisition compared to the first (P<0001). In seven of 25 patients (28%) and in seven of 13 patients with BSI>0 (54%), a clinically significant increase (>03) was observed. The time between injection and scanning should be fixed when changes in BSI are important, for example when monitoring therapeutic efficacy.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

bone metastases

bone scan quantitative analysis

computer-assisted diagnostic software

imaging biomarker

prostate cancer

reproducibility

resistant prostate-cancer

guidelines

biomarker

hdp

Physiology

Bone metastases

Bone scan quantitative analysis

Computer-assisted diagnostic software

Imaging biomarker

Prostate cancer

Reproducibility

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)