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Genome-wide meta-an...
Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain
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- Suri, P. (författare)
- University of Washington,VA Puget Sound Health Care System,U.S. Department of Veterans Affairs
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- Palmer, M. R. (författare)
- University of Washington
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- Tsepilov, Y. A. (författare)
- Novosibirsk State University,The Federal Research Center Institute of Cytology and Genetics
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visa fler...
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- Freidin, M. B. (författare)
- King's College London
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- Boer, C. G. (författare)
- Erasmus University Medical Center
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- Yau, M. S. (författare)
- Beth Israel Deaconess Medical Center,Harvard University,Hebrew SeniorLife
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- Evans, D. S. (författare)
- California Pacific Medical Center
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- Gelemanovic, A. (författare)
- University of Split
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- Bartz, T. M. (författare)
- University of Washington
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- Nethander, Maria, 1980 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Core Facilities, Bioinformatics,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Core Facilities, Bioinformatics,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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- Arbeeva, L. (författare)
- University of North Carolina
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- Karssen, L. (författare)
- PolyOmica
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- Neogi, T. (författare)
- Boston University
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- Campbel, A. (författare)
- University of Edinburgh
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- Mellström, Dan, 1945 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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- Ohlsson, Claes, 1965 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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- Marshall, L. M. (författare)
- Oregon Health & Science University
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- Orwoll, E. (författare)
- Oregon Health & Science University
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- Uitterlinden, A. (författare)
- Erasmus University Medical Center
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- Rotter, J. I. (författare)
- University of California, Los Angeles,Harbor–UCLA Medical Center
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- Lauc, G. (författare)
- Genos d.o.o,University of Zagreb
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- Psaty, B. M. (författare)
- Kaiser Permanente Research Institute,University of Washington
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- Karlsson, Magnus K. (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Skåne University Hospital,King's College London
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- Lane, N. E. (författare)
- University of California, Davis
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- Jarvik, G. P. (författare)
- University of Washington
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- Polasek, O. (författare)
- Psychiatric Hospital "Sveti Ivan",University of Split
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- Hochberg, M. (författare)
- University of Maryland, Baltimore
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- Jordan, J. M. (författare)
- University of North Carolina,Erasmus University Medical Center
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Van Meurs, J. B. J. (författare)
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- Jackson, R. (författare)
- Ohio State University
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- Nielson, C. M. (författare)
- Oregon Health & Science University
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- Mitchell, B. D. (författare)
- Veterans Health Administration,University of Maryland, Baltimore
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- Smith, B. H. (författare)
- University of Dundee
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- Hayward, C. (författare)
- University of Edinburgh
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- Smith, N. L. (författare)
- University of Washington,Kaiser Permanente Research Institute,U.S. Department of Veterans Affairs
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- Aulchenko, Y. S. (författare)
- PolyOmica
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Williams, F. M. K. (författare)
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visa färre...
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(creator_code:org_t)
- 2018-09-27
- 2018
- Engelska.
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Ingår i: PLoS Genet. - : Public Library of Science (PLoS). - 1553-7404 .- 1553-7390. ; 14:9
- Relaterad länk:
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https://journals.plo...
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Back pain is the #1 cause of years lived with disability worldwide, yet surprisingly little is known regarding the biology underlying this symptom. We conducted a genome-wide association study (GWAS) meta-analysis of chronic back pain (CBP). Adults of European ancestry were included from 15 cohorts in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, and from the UK Biobank interim data release. CBP cases were defined as those reporting back pain present for >= 3-6 months; non-cases were included as comparisons ("controls"). Each cohort conducted genotyping using commercially available arrays followed by imputation. GWAS used logistic regression models with additive genetic effects, adjusting for age, sex, study-specific covariates, and population substructure. The threshold for genome-wide significance in the fixed-effect inverse-variance weighted meta-analysis was p<5x10(-8). Suggestive (p<5x10(-7)) and genome-wide significant (p<5x10(-8)) variants were carried forward for replication or further investigation in the remaining UK Biobank participants not included in the discovery sample. The discovery sample comprised 158,025 individuals, including 29,531 CBP cases. A genome-wide significant association was found for the intronic variant rs12310519 in SOX5 (OR 1.08, p = 7.2x10(-10)). This was subsequently replicated in 283,752 UK Biobank participants not included in the discovery sample, including 50,915 cases (OR 1.06, p= 5.3x10(-11)), and exceeded genome-wide significance in joint meta-analysis (OR 1.07, p= 4.5x10(-19)). We found suggestive associations at three other loci in the discovery sample, two of which exceeded genome-wide significance in joint meta-analysis: an intergenic variant, rs7833174, located between CCDC26 and GSDMC (OR 1.05, p = 4.4x10(-13)), and an intronic variant, rs4384683, in DCC (OR 0.97, p = 2.4x10(-19)). In this first reported meta-analysis of GWAS for CBP, we identified and replicated a genetic locus associated with CBP (SOX5). We also identified 2 other loci that reached genome-wide significance in a 2-stage joint meta-analysis (CCDC26/GSDMC and DCC).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
Nyckelord
- ld score regression
- body-mass index
- genetic-variants
- intervertebral
- disc
- knee osteoarthritis
- cotwin control
- risk-factors
- heritability
- netrin-1
- traits
- Genetics & Heredity
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Suri, P.
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Palmer, M. R.
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Tsepilov, Y. A.
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Freidin, M. B.
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Boer, C. G.
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Yau, M. S.
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visa fler...
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Evans, D. S.
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Gelemanovic, A.
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Bartz, T. M.
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Nethander, Maria ...
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Arbeeva, L.
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Karssen, L.
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Neogi, T.
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Campbel, A.
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Mellström, Dan, ...
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Ohlsson, Claes, ...
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Marshall, L. M.
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Orwoll, E.
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Uitterlinden, A.
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Rotter, J. I.
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Lauc, G.
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Psaty, B. M.
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Karlsson, Magnus ...
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Lane, N. E.
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Jarvik, G. P.
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Polasek, O.
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Hochberg, M.
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Jordan, J. M.
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Van Meurs, J. B. ...
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Jackson, R.
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Nielson, C. M.
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Mitchell, B. D.
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Smith, B. H.
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Hayward, C.
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Smith, N. L.
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Aulchenko, Y. S.
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Williams, F. M. ...
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visa färre...
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Medicinsk geneti ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Ortopedi
- Artiklar i publikationen
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PLoS Genet
- Av lärosätet
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Göteborgs universitet
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Lunds universitet