Inflammatory markers of CHMP2B-mediated frontotemporal dementia

• Histopathological studies and animal models have suggested an inflammatory component in the patho-mechanism of the CHMP2B associated frontotemporal dementia (FTD-3). In this cross-sectional study, serum and cerebrospinal fluid were analyzed for inflammatory markers in CHMP2B mutation carriers. Serum levels of CCL4 were increased throughout life. Serum levels of IL-15, CXCL10, CCL22 and TNF-alpha were significantly associated with cognitive decline, suggesting a peripheral inflammatory response to neurodegeneration. CSF levels of sTREM2 appeared to increase more rapidly with age in CHMP2B mutation carriers. The identification of a peripheral inflammatory response to disease progression supports the involvement of an inflammatory component in FTD-3.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Keyword

Autosomal dominantly inherited frontotemporal dementia

Chromosome 3-linked frontotemporal

cerebrospinal-fluid biomarkers

immunodeficiency-virus type-1

chmp2b

mutation carriers

alzheimers-disease

lobar degeneration

chromosome-3

injury

microglia

pathology

genetics

Publication and Content Type

ref (subject category)

art (subject category)