Risk Factors for Ventricular Septal Defects in Murmansk County, Russia: A Registry-Based Study

Kovalenko, A. A.The Arctic University of Norway, Tromsø, Norway / Northern State Medical University, Arkhangelsk, Russia (författare)

CC BY 4.0
Cardiovascular malformations are one of the most common birth defects among newborns and constitute a leading cause of perinatal and infant mortality. Although some risk factors are recognized, the causes of cardiovascular malformations (CVMs) remain largely unknown. In this study, we aim to identify risk factors for ventricular septal defects (VSDs) in Northwest Russia. The study population included singleton births registered in the Murmansk County Birth Registry (MCBR) between 1 January 2006 and 31 December 2011. Infants with a diagnosis of VSD in the MCBR and/or in the Murmansk Regional Congenital Defects Registry (up to two years post-delivery) constituted the study sample. Among the 52,253 infants born during the study period there were 744 cases of septal heart defects (SHDs), which corresponds to a prevalence of 14.2 [95% confidence interval (CI) of 13.2-15.3] per 1000 infants. Logistic regression analyses were carried out to identify VSD risk factors. Increased risk of VSDs was observed among infants born to mothers who abused alcohol [OR = 4.83; 95% CI 1.88-12.41], or smoked during pregnancy [OR = 1.35; 95% CI 1.02-1.80]. Maternal diabetes mellitus was also a significant risk factor [OR = 8.72; 95% CI 3.16-24.07], while maternal age, body mass index, folic acid and multivitamin intake were not associated with increased risk. Overall risks of VSDs for male babies were lower [OR = 0.67; 95% CI 0.52-0.88].

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
registry
risk factors
ventricular septal defects
congenital heart-defects
fetal alcohol syndrome
maternal smoking
birth-defects
cardiovascular malformations
global prevalence
pregnancy
metaanalysis
disease
epidemiology
Environmental Sciences & Ecology
Public
Environmental & Occupational
Health
registry
Individual and Society VIDSOC

Anda, E. E.The Arctic University of Norway, Tromsø, Norway (författare)
Odland, J. O.The Arctic University of Norway, Tromsø, Norway (författare)
Nieboer, E.McMaster University, Hamilton, ON, Canada (författare)
Brenn, T.The Arctic University of Norway, Tromsø, Norway (författare)
Krettek, Alexandra,1968Högskolan i Skövde,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Institutionen för hälsa och lärande,Forskningsspecialiseringen Hälsa och Lärande,The Arctic University of Norway, Tromsø, Norway / Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden,Individ och Samhälle (VIDSOC), Individual and Society(Swepub:his)krea (författare)
The Arctic University of Norway, Tromsø, Norway / Northern State Medical University, Arkhangelsk, RussiaThe Arctic University of Norway, Tromsø, Norway (creator_code:org_t)

Ingår i:International Journal of Environmental Research and Public Health: MDPI AG15:71660-46011661-7827

Av författaren/redakt...: Kovalenko, A. A.; Anda, E. E.; Odland, J. O.; Nieboer, E.; Brenn, T.; Krettek, Alexand ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Folkhälsovetensk ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.