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The associations of...
The associations of advanced glycation end products and its soluble receptor with pancreatic cancer risk: A case-control study within the prospective EPIC cohort
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Grote, Verena A. (author)
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Nieters, Alexandra (author)
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Kaaks, Rudolf (author)
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show more...
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Tjnøneland, Anne (author)
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Roswall, Nina (author)
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Overvad, Kim (author)
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Skjelbo Nielsen, Michael R. (author)
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Clavel-Chapelon, Franco̧ise (author)
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Boutron-Ruault, Marie Christine (author)
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Racine, Antoine (author)
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Teucher, Birgit (author)
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Lukanova, Annekatrin (author)
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Boeing, Heiner (author)
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Drogan, Dagmar (author)
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Trichopoulou, Antonia (author)
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Trichopoulos, Dimitrios (author)
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Lagiou, Pagona (author)
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Palli, Domenico (author)
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Sieri, Sabina (author)
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Tumino, Rosario (author)
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Vineis, Paolo (author)
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Mattiello, Amalia (author)
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Suaŕez, Marcial Vicente Arguëlles (author)
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Duell, Eric J. (author)
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Sańchez, Mariá José (author)
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Dorronsoro, Miren (author)
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Castanõ, José María Huerta (author)
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Barricarte, Aurelio (author)
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Jeurnink, Suzanne M. (author)
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Peeters, Petra H.M. (author)
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- Sund, Malin, 1972- (author)
- Umeå universitet,Kirurgi,Malin Sund
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- Ye, Weimin (author)
- Karolinska Institutet
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- Regnér, Sara (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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- Lindkvist, Björn (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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Khaw, Kay Tee (author)
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Wareham, Nick (author)
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Allen, Naomi E. (author)
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Crowe, Francesca L. (author)
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Fedirko, Veronika (author)
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Jenab, Mazda (author)
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Romaguera, Dora (author)
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Siddiq, Afshan (author)
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Bueno-de-Mesquita, H. Bas (author)
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Rohrmann, Sabine (author)
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(creator_code:org_t)
- 2012
- 2012
- English.
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In: Cancer Epidemiology Biomarkers and Prevention. - 1055-9965 .- 1538-7755. ; 21:4, s. 619-628
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Abstract
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- Background: Advanced glycation end products (AGE) and their receptors (RAGE) have been implicated in cancer development through their proinflammatory capabilities. However, prospective data on their association with cancer of specific sites, including pancreatic cancer, are limited. Methods: Prediagnostic blood levels of the AGE product Nε-(carboxymethyl)lysine (CML) and the endogenous secreted receptor for AGE (esRAGE) were measured using ELISA in 454 patients with exocrine pancreatic cancer and individually matched controls within the European Prospective Investigation into Cancer and Nutrition (EPIC). Pancreatic cancer risk was estimated by calculating ORs with corresponding 95% confidence intervals (CI). Results: Elevated CML levels tended to be associated with a reduction in pancreatic cancer risk [OR = 0.57 (95% CI, 0.32-1.01) comparing highest with lowest quintile), whereas no association was observed for esRAGE (OR = 0.98; 95% CI, 0.62-1.54). Adjustments for body mass index and smoking attenuated the inverse associations of CML with pancreatic cancer risk (OR = 0.78; 95% CI, 0.41-1.49). There was an inverse association between esRAGE and risk of pancreatic cancer for cases that were diagnosed within the first 2 years of follow-up [OR = 0.46 (95% CI, 0.22-0.96) for a doubling in concentration], whereas there was no association among those with a longer follow-up (OR = 1.11; 95% CI, 0.88-1.39; P interaction = 0.002). Conclusions and Impact: Our results do not provide evidence for an association of higher CML or lower esRAGE levels with risk of pancreatic cancer. The role of AGE/RAGE in pancreatic cancer would benefit from further investigations. ©2012 AACR.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
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- art (subject category)
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- By the author/editor
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Grote, Verena A.
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Nieters, Alexand ...
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Kaaks, Rudolf
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Tjnøneland, Anne
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Roswall, Nina
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Overvad, Kim
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show more...
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Skjelbo Nielsen, ...
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Clavel-Chapelon, ...
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Boutron-Ruault, ...
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Racine, Antoine
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Teucher, Birgit
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Lukanova, Anneka ...
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Boeing, Heiner
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Drogan, Dagmar
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Trichopoulou, An ...
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Trichopoulos, Di ...
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Lagiou, Pagona
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Palli, Domenico
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Sieri, Sabina
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Tumino, Rosario
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Vineis, Paolo
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Mattiello, Amali ...
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Suaŕez, Marcial ...
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Duell, Eric J.
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Sańchez, Mariá J ...
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Dorronsoro, Mire ...
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Castanõ, José Ma ...
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Barricarte, Aure ...
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Jeurnink, Suzann ...
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Peeters, Petra H ...
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Sund, Malin, 197 ...
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Ye, Weimin
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Regnér, Sara
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Lindkvist, Björn
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Khaw, Kay Tee
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Wareham, Nick
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Allen, Naomi E.
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Crowe, Francesca ...
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Fedirko, Veronik ...
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Jenab, Mazda
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Romaguera, Dora
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Siddiq, Afshan
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Bueno-de-Mesquit ...
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Rohrmann, Sabine
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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Cancer Epidemiol ...
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Cancer epidemiol ...
- By the university
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University of Gothenburg
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Lund University
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Karolinska Institutet
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Umeå University