Renal Function and Remission of Hypertension After Bariatric Surgery: a 5-Year Prospective Cohort Study

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Neff, Karl J. (author)

Renal Function and Remission of Hypertension After Bariatric Surgery: a 5-Year Prospective Cohort Study

Article/chapterEnglish2017

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2016-09-14
Springer Science and Business Media LLC,2017

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LIBRIS-ID:oai:gup.ub.gu.se/273317
https://gup.ub.gu.se/publication/273317URI
https://doi.org/10.1007/s11695-016-2333-7DOI

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Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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© 2016, Springer Science+Business Media New York. Purpose: This study examines the effect of Roux-en-Y gastric bypass (RYGB) and laparoscopic adjustable gastric banding (LAGB) on renal function for at least 5years post-operatively in a tertiary referral center for bariatric surgery. Materials and Methods: This prospective cohort study of patients undergoing RYGB and LAGB measured renal function, blood pressure, and diabetes status pre-operatively and then 1 and 5years post-operatively. Renal function was assessed using the Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), and Cockcroft-Gault formulae. Hypertension and diabetes were defined by the European Society of Hypertension and European Society of Cardiology joint guidelines and American Diabetes Association guidelines, respectively. A sub-group who had completed 10years post-operative follow-up was also included. Results: Estimated glomerular filtration rate (eGFR) increased over 5years after RYGB (N = 190; 94 ± 2mL/min/1.73m2 to 102 ± 22mL/min/1.73m2, p = 0.01) and LAGB (N = 271; 88 ± 1 to 93 ± 22mL/min/1.73m2, p = 0.02). In a sub-group with up to 10years post-operative date, this trend was maintained. In patients with renal impairment, eGFR improved over 5years (52 ± 2 to 68 ± 7mL/min/1.73m2, p = 0.01). Remission of hypertension was greater after RYGB than LAGB at 1year (32 vs. 16%, p = 0.008) and at 5years post-operatively (23 vs. 11%, p = 0.02). Conclusions: Bariatric surgery stabilizes eGFR post-operatively for at least 5years. In a sub-group with renal impairment, eGFR is increased in the first post-operative year and this is maintained for up to 5years. RYGB is an effective procedure in achieving blood pressure control.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Urologi och njurmedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Urology and Nephrology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
Banding
Bariatric surgery
Hypertension
Kidney disease
Renal function
RYGB

Added entries (persons, corporate bodies, meetings, titles ...)

Baud, Gregory (author)
Raverdy, Violeta (author)
Caiazzo, Robert (author)
Verkindt, Helene (author)
Noel, Christian (author)
le Roux, Carel WGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning,Institute of Clinical Sciences, Department of Gastrosurgical Research and Education(Swepub:gu)xleroc (author)
Pattou, François (author)
Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning (creator_code:org_t)

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In:Obesity Surgery: Springer Science and Business Media LLC27, s. 613-6190960-89231708-0428

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By the author/editor: Neff, Karl J.; Baud, Gregory; Raverdy, Violeta; Caiazzo, Robert; Verkindt, Helene; Noel, Christian; show more...; le Roux, Carel W; Pattou, François; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Urology and Neph ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Surgery

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