Disability, fatigue, pain and their associates in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational Study.

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MARC

Peytrignet, SébastienUniversity of Manchester (author)

Disability, fatigue, pain and their associates in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational Study.

Article/chapterEnglish2018

Publisher, publication year, extent ...

2017-11-30
Oxford University Press (OUP),2018

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LIBRIS-ID:oai:gup.ub.gu.se/274170
https://gup.ub.gu.se/publication/274170URI
https://doi.org/10.1093/rheumatology/kex410DOI
https://lup.lub.lu.se/record/83ea9c36-b12b-4ceb-949f-1df6eaef521eURI

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Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Our aim was to describe the burden of early dcSSc in terms of disability, fatigue and pain in the European Scleroderma Observational Study cohort, and to explore associated clinical features.Patients completed questionnaires at study entry, 12 and 24 months, including the HAQ disability index (HAQ-DI), the Cochin Hand Function Scale (CHFS), the Functional Assessment of Chronic Illness Therapy-fatigue and the Short Form 36 (SF36). Associates examined included the modified Rodnan skin score (mRSS), current digital ulcers and internal organ involvement. Correlations between 12-month changes were also examined.The 326 patients recruited (median disease duration 11.9 months) displayed high levels of disability [mean (s.d.) HAQ-DI 1.1 (0.83)], with 'grip' and 'activity' being most affected. Of the 18 activities assessed in the CHFS, those involving fine finger movements were most affected. High HAQ-DI and CHFS scores were both associated with high mRSS (ρ = 0.34, P < 0.0001 and ρ = 0.35, P < 0.0001, respectively). HAQ-DI was higher in patients with digital ulcers (P = 0.004), pulmonary fibrosis (P = 0.005), cardiac (P = 0.005) and muscle involvement (P = 0.002). As anticipated, HAQ-DI, CHFS, the Functional Assessment of Chronic Illness Therapy and SF36 scores were all highly correlated, in particular the HAQ-DI with the CHFS (ρ = 0.84, P < 0.0001). Worsening HAQ-DI over 12 months was strongly associated with increasing mRSS (ρ = 0.40, P < 0.0001), decreasing hand function (ρ = 0.57, P < 0.0001) and increasing fatigue (ρ = -0.53, P < 0.0001).The European Scleroderma Observational Study highlights the burden of disability in early dcSSc, with high levels of disability and fatigue, associating with the degree of skin thickening (mRSS). Impaired hand function is a major contributor to overall disability.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reumatologi och inflammation hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Rheumatology and Autoimmunity hsv//eng
Adult
Cost of Illness
Disability Evaluation
Europe
Fatigue
etiology
physiopathology
Female
Fingers
Hand Strength
Health Surveys
Humans
Male
Pain
etiology
physiopathology
Prospective Studies
Scleroderma
Diffuse
complications
physiopathology
Severity of Illness Index
Skin Ulcer
etiology
physiopathology
Disability
Early diffuse cutaneous systemic sclerosis
Hand function

Added entries (persons, corporate bodies, meetings, titles ...)

Denton, Christopher PUniversity College London (author)
Lunt, MarkUniversity of Manchester (author)
Hesselstrand, RogerLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-rhe (author)
Mouthon, LucParis Descartes University (author)
Silman, AlanUniversity of Oxford (author)
Pan, XiaoyanUniversity of Manchester (author)
Brown, EdithUniversity of Manchester (author)
Czirják, LászlóUniversity of Pécs (author)
Distler, Jörg H WFriedrich-Alexander University Erlangen-Nürnberg (author)
Distler, OliverUniversity of Zurich (author)
Fligelstone, KimUniversity College London (author)
Gregory, William JGreat Ormond Street Hospital (author)
Ochiel, RachelUniversity College London (author)
Vonk, MadelonRadboud University Nijmegen (author)
Ancuta, CodrinaGrigore T. Popa University of Medicine and Pharmacy (author)
Ong, Voon HUniversity College London (author)
Farge, DominiqueSaint-Louis Hospital, Paris (author)
Hudson, MarieMcGill University,Jewish General Hospital (author)
Matucci-Cerinic, MarcoUniversity of Florence (author)
Balbir-Gurman, AlexandraTechnion - Israel Institute of Technology (author)
Midtvedt, ØyvindNorwegian Radium Hospital (author)
Jordan, Alison CNew Queen Elizabeth Hospital (author)
Stevens, WendySt. Vincent's Hospital, Melbourne (author)
Moinzadeh, PiaUniversity of Cologne (author)
Hall, Frances CUniversity of Cambridge (author)
Agard, ChristianUniversity of Nantes (author)
Anderson, Marina EUniversity of Liverpool (author)
Diot, ElisabethHopital Bretonneau (author)
Madhok, RajanGlasgow Royal Infirmary (author)
Akil, MohammedSheffield Teaching Hospitals (author)
Buch, Maya HLeeds Teaching Hospitals NHS Trust,University of Leeds (author)
Chung, LorindaStanford University (author)
Damjanov, NemanjaUniversity of Belgrade (author)
Gunawardena, HarshaNorth Bristol NHS Trust (author)
Lanyon, PeterNottingham NHS Treatment Centre,Nottingham University Hospitals NHS Trust (author)
Ahmad, YasmeenLlandudno Hospital (author)
Chakravarty, KuntalQueen's Hospital, Romford (author)
Jacobsen, SørenUniversity of Copenhagen (author)
MacGregor, Alexander JUniversity of East Anglia (author)
McHugh, NeilRoyal National Hospital for Rheumatic Diseases (author)
Müller-Ladner, UlfJustus Liebig University Giessen (author)
Riemekasten, GabrielaBritish Columbia Children's Hospital (author)
Becker, MichaelCharité - University Medicine Berlin (author)
Roddy, JanetRoyal Perth Hospital (author)
Carreira, Patricia E12 de Octubre University Hospital (author)
Fauchais, Anne LaureUniversity Hospital Of Limoges (author)
Hachulla, EricUniversity of Lille (author)
Hamilton, JenniferGateshead Hospitals Foundation Trust (author)
Inanç, MuratIstanbul University (author)
McLaren, John SWhyteman's Brae Hospital (author)
van Laar, Jacob MUniversity Medical Center Utrecht (author)
Pathare, SanjayJames Cook University Hospital (author)
Proudman, SusannaUniversity of Adelaide (author)
Rudin, Anna,1961Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Sahlgrenska Academy(Swepub:gu)xrudan (author)
Sahhar, JoanneMonash University (author)
Serratrice, ChristineHospital Saint Joseph (author)
Sheeran, TomCannock Chase Hospital (author)
Veale, Douglas JSt Vincent's University Hospital (author)
Grange, ClaireCentre Hospitalier Lyon Sud (author)
Trad, Georges-SelimCHU Ambroise Paré (author)
Herrick, Ariane LUniversity of Manchester,Christie NHS Foundation Trust (author)
Coppere, BrigitteHôpital Edouard Herriot (author)
University of ManchesterUniversity College London (creator_code:org_t)

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In:Rheumatology (Oxford, England): Oxford University Press (OUP)57:2, s. 370-3811462-03321462-0324

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By the author/editor: Peytrignet, Séba ...; Denton, Christop ...; Lunt, Mark; Hesselstrand, Ro ...; Mouthon, Luc; Silman, Alan; show more...; Pan, Xiaoyan; Brown, Edith; Czirják, László; Distler, Jörg H ...; Distler, Oliver; Fligelstone, Kim; Gregory, William ...; Ochiel, Rachel; Vonk, Madelon; Ancuta, Codrina; Ong, Voon H; Farge, Dominique; Hudson, Marie; Matucci-Cerinic, ...; Balbir-Gurman, A ...; Midtvedt, Øyvind; Jordan, Alison C; Stevens, Wendy; Moinzadeh, Pia; Hall, Frances C; Agard, Christian; Anderson, Marina ...; Diot, Elisabeth; Madhok, Rajan; Akil, Mohammed; Buch, Maya H; Chung, Lorinda; Damjanov, Nemanj ...; Gunawardena, Har ...; Lanyon, Peter; Ahmad, Yasmeen; Chakravarty, Kun ...; Jacobsen, Søren; MacGregor, Alexa ...; McHugh, Neil; Müller-Ladner, U ...; Riemekasten, Gab ...; Becker, Michael; Roddy, Janet; Carreira, Patric ...; Fauchais, Anne L ...; Hachulla, Eric; Hamilton, Jennif ...; Inanç, Murat; McLaren, John S; van Laar, Jacob ...; Pathare, Sanjay; Proudman, Susann ...; Rudin, Anna, 196 ...; Sahhar, Joanne; Serratrice, Chri ...; Sheeran, Tom; Veale, Douglas J; Grange, Claire; Trad, Georges-Se ...; Herrick, Ariane ...; Coppere, Brigitt ...; show less...

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