L773:0022 3077
Sökning: L773:0022 3077 > (2015-2019) > Microneurography as...
- Ackerley, Rochelle,1980Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology (författare)
Microneurography as a tool to study the function of individual C-fiber afferents in humans: responses from nociceptors, thermoreceptors, and mechanoreceptors
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
- American Physiological Society,2018
Nummerbeteckningar
- LIBRIS-ID:oai:gup.ub.gu.se/274386
- https://gup.ub.gu.se/publication/274386URI
- https://doi.org/10.1152/jn.00109.2018DOI
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- Språk:engelska
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- The technique of microneurography-recording neural traffic from nerves in awake humans-has provided us with unrivaled insights into afferent and efferent processes in the peripheral nervous system for over 50 years. We review the use of microneurography to study single C-fiber afferents and provide an overview of the knowledge gained, with views to future investigations. C-fibers have slowly conducting, thin-diameter, unmyelinated axons and make up the majority of the fibers in peripheral nerves (similar to 80%). With the use of microneurography in humans, C-fiber afferents have been differentiated into discrete subclasses that encode specific qualities of stimuli on the skin, and their functional roles have been investigated. Afferent somatosensory information provided by C-fibers underpins various positive and negative affective sensations from the periphery, including mechanical, thermal, and chemical pain (C-nociceptors), temperature (C-thermoreceptors), and positive affective aspects of touch (C-tactile afferents). Insights from microneurographic investigations have revealed the complexity of the C-fiber system, methods for delineating fundamental C-fiber populations in a translational manner, how C-fiber firing can be used to identify nerve deficits in pathological states, and how the responses from C-fibers may be modified to change sensory percepts, including decreasing pain. Understanding these processes may lead to future medical interventions to diagnose and treat C-fiber dysfunction. NEW & NOTEWORTHY The technique of microneurography allows us to directly investigate the functional roles of single C-fiber afferents in awake human beings. Here we outline and discuss the current field of C-fiber research on this heterogeneous population of afferents in healthy subjects, in pathological states, and from a translational perspective. We cover C-fibers encoding touch, temperature, and pain and provide perspectives on the future of C-fiber microneurography investigations in humans.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
- C-fiber
- mechanoreceptor
- microneurography
- nociception
- pain
- temperature
- touch
- mechano-insensitive nociceptors
- unmyelinated tactile afferents
- velocity recovery cycles
- human-skin
- electrical-stimulation
- intraneural microstimulation
- innervation territories
- conduction-velocity
- heat stimulation
- low-temperature
- Neurosciences & Neurology
- Physiology
- hmelz m
- 1995
- experimental brain research
- v104
- p331
- hmidt r
- 1995
- journal of neuroscience
- v15
- p333
- hmelz m
- 1994
- journal of physiology-london
- v480
- p389
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Watkins, Roger H.,1988Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology(Swepub:gu)xholro (författare)
- Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för fysiologi (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Journal of Neurophysiology: American Physiological Society120:6, s. 2834-28460022-30771522-1598
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