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Data driven diagnos...
Data driven diagnostic classification in Alzheimer's disease based on different reference regions for normalization of PiB-PET images and correlation with CSF concentrations of A beta species
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Oliveira, F. (author)
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Leuzy, A. (author)
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Castelhano, J. (author)
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- Chiotis, K. (author)
- Karolinska Institutet
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Hasselbalch, S. G. (author)
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Rinne, J. (author)
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Mendonca, A. (author)
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Otto, M. (author)
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Lleo, A. (author)
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Santana, I. (author)
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Johansson, J. (author)
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Anderl-Straub, S. (author)
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Arnim, C. (author)
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Beer, A. (author)
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Blesa, R. (author)
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Fortea, J. (author)
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Sanna-Kaisa, H. (author)
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- Portelius, Erik, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Pannee, Josef, 1979 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Moreira, A. P. (author)
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- Abrunhosa, A. (author)
- Karolinska Institutet
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Nordberg, A. (author)
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Castelo-Branco, M. (author)
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English.
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In: Neuroimage-Clinical. - : Elsevier BV. - 2213-1582. ; 20, s. 603-610
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https://doi.org/10.1...
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Abstract
Subject headings
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- Positron emission tomography (PET) neuroimaging with the Pittsburgh Compound_B (PiB) is widely used to assess amyloid plaque burden. Standard quantification approaches normalize PiB-PET by mean cerebellar gray matter uptake. Previous studies suggested similar pons and white-matter uptake in Alzheimer's disease (AD) and healthy controls (HC), but lack exhaustive comparison of normalization across the three regions, with data-driven diagnostic classification. We aimed to compare the impact of distinct reference regions in normalization, measured by data-driven statistical analysis, and correlation with cerebrospinal fluid (CSF) amyloid beta (A beta) species concentrations. 243 individuals with clinical diagnosis of AD, HC, mild cognitive impairment (MCI) and other dementias, from the Biomarkers for Alzheimer's/Parkinson's Disease (BIOMARKAPD) initiative were included. PiB-PET images and CSF concentrations of A beta(38), A beta(40) and A beta(42) were submitted to classification using support vector machines. Voxel-wise group differences and correlations between normalized PiB-PET images and CSF A beta concentrations were calculated. Normalization by cerebellar gray matter and pons yielded identical classification accuracy of AD (accuracy-96%, sensitivity-96%, specificity-95%), and significantly higher than A beta concentrations (best accuracy 91%). Normalization by the white-matter showed decreased extent of statistically significant multivoxel patterns and was the only method not outperforming CSF biomarkers, suggesting statistical inferiority. A beta(38) and A beta(40) correlated negatively with PiB-PET images normalized by the white-matter, corroborating previous observations of correlations with non-AD-specific subcortical changes in white-matter. In general, when using the pons as reference region, higher voxel-wise group differences and stronger correlation with A beta(42), the A beta(42)/A beta(40) or A beta(42)/A beta(38) ratios were found compared to normalization based on cerebellar gray matter.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- mild cognitive impairment
- amyloid-beta
- task-force
- quantification
- conversion
- medicine
- criteria
- markers
- mci
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Oliveira, F.
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Leuzy, A.
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Castelhano, J.
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Chiotis, K.
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Hasselbalch, S. ...
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Rinne, J.
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show more...
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Mendonca, A.
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Otto, M.
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Lleo, A.
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Santana, I.
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Johansson, J.
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Anderl-Straub, S ...
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Arnim, C.
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Beer, A.
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Blesa, R.
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Fortea, J.
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Sanna-Kaisa, H.
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Portelius, Erik, ...
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Pannee, Josef, 1 ...
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Moreira, A. P.
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Abrunhosa, A.
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Nordberg, A.
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Castelo-Branco, ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Neuroimage-Clini ...
- By the university
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University of Gothenburg
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Karolinska Institutet