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Regional estimates ...
Regional estimates of cortical thickness in brain areas involved in control of surgically restored limb movement in patients with tetraplegia.
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- Bunketorp Käll, Lina, 1975 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Sahlgrenska Univ Hosp Molndal, Sweden; Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden
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- Fridén, Jan, 1953 (författare)
- Sahlgrenska Univ Hosp Molndal, Sweden; Swiss Parapleg Ctr, Switzerland
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- Björnsdotter, Malin (författare)
- Linköpings universitet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Univ Gothenburg, Sweden
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(creator_code:org_t)
- 2018-10-23
- 2020
- Engelska.
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Ingår i: The journal of spinal cord medicine. - : Informa UK Limited. - 2045-7723 .- 1079-0268. ; 43:4, s. 462-469
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Abstract
Ämnesord
Stäng
- Spinal cord injury (SCI) causes atrophy of brain regions linked to motor function. We aimed to estimate cortical thickness in brain regions that control surgically restored limb movement in individuals with tetraplegia.Cross-sectional study.Sahlgrenska University hospital, Gothenburg, Sweden.Six individuals with tetraplegia who had undergone surgical restoration of grip function by surgical transfer of one elbow flexor (brachioradialis), to the paralyzed thumb flexor (flexor pollicis longus). All subjects were males, with a SCI at the C6 or C7 level, and a mean age of 40 years (range=31-48). The average number of years elapsed since the SCI was 13 (range=6-26).We used structural magnetic resonance imaging (MRI) to estimate the thickness of selected motor cortices and compared these measurements to those of six matched control subjects. The pinch grip control area was defined in a previous functional MRI study.Compared to controls, the cortical thickness in the functionally defined pinch grip control area was not significantly reduced (P=0.591), and thickness showed a non-significant but positive correlation with years since surgery in the individuals with tetraplegia. In contrast, the anatomically defined primary motor cortex as a whole exhibited substantial atrophy (P=0.013), with a weak negative correlation with years since surgery.Individuals with tetraplegia do not seem to have reduced cortical thickness in brain regions involved in control of surgically restored limb movement. However, the studied sample is very small and further studies with larger samples are required to establish these findings.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Tetraplegia; Reconstructive surgical procedure; Upper limb; Cortical reorganization; MRI (magnetic resonance imaging)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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