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Interplay between g...
Interplay between genetic predisposition, macronutrient intake and type 2 diabetes incidence: analysis within EPIC-InterAct across eight European countries.
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- Li, Sherly X (författare)
- University of Cambridge
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- Imamura, Fumiaki (författare)
- University of Cambridge
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- Schulze, Matthias B (författare)
- German Institute of Human Nutrition,German Center for Diabetes Research
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visa fler...
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- Zheng, Jusheng (författare)
- University of Cambridge
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- Ye, Zheng (författare)
- University of Cambridge
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- Agudo, Antonio (författare)
- Catalan Institute of Oncology,University of Cambridge
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- Ardanaz, Eva (författare)
- Health Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP)
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- Aune, Dagfinn (författare)
- Imperial College London,Bjørknes University College
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- Boeing, Heiner (författare)
- German Institute of Human Nutrition
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- Dorronsoro, Miren (författare)
- Public Health Division of Gipuzkoa,Biodonostia Health Research Institute,CIBER Epidemiology and Public Health (CIBERESP)
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- Dow, Courtney (författare)
- University of Paris-Saclay,Versailles Saint-Quentin-en-Yvelines University
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- Fagherazzi, Guy (författare)
- Versailles Saint-Quentin-en-Yvelines University,University of Paris-Saclay
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- Grioni, Sara (författare)
- Istituto Nazionale dei Tumori
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- Gunter, Marc J (författare)
- International Agency for Research on Cancer, World Health Organization
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- Huerta, José María (författare)
- CIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council
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- Ibsen, Daniel B (författare)
- Aarhus University
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- Jakobsen, Marianne Uhre (författare)
- Aarhus University,Technical University of Denmark
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- Kaaks, Rudolf (författare)
- German Cancer Research Centre
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- Key, Timothy J (författare)
- University of Oxford
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- Khaw, Kay-Tee (författare)
- University of Cambridge
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- Kyrø, Cecilie (författare)
- Danish Cancer Society
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- Mancini, Francesca Romana (författare)
- Versailles Saint-Quentin-en-Yvelines University,University of Paris-Saclay
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- Molina-Portillo, Elena (författare)
- CIBER Epidemiology and Public Health (CIBERESP),University of Granada
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- Murphy, Neil (författare)
- International Agency for Research on Cancer, World Health Organization
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- Nilsson, Peter M. (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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- Onland-Moret, N Charlotte (författare)
- University Medical Center Utrecht
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- Palli, Domenico (författare)
- Cancer Research and Prevention Institute (ISPO)
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- Panico, Salvatore (författare)
- University of Naples Federico II
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- Poveda, Alaitz (författare)
- Umeå University,Lund University,Lunds universitet,Umeå universitet,Institutionen för omvårdnad,Department of Clinical Sciences, Clinical Research Center, Skåne University Hospital, Lund University, Malmö, Sweden,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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- Quirós, J Ramón (författare)
- Public Health Directorate
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- Ricceri, Fulvio (författare)
- University of Turin
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- Sluijs, Ivonne (författare)
- University Medical Center Utrecht
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- Spijkerman, Annemieke M W (författare)
- National Institute for Public Health and the Environment (RIVM)
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- Tjonneland, Anne (författare)
- Danish Cancer Society
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- Tumino, Rosario (författare)
- Associazione Iblea per la Ricerca Epidemiologica,Civic and M.P Arezzo Hospital
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- Winkvist, Anna, 1962 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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- Langenberg, Claudia (författare)
- University of Cambridge
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- Sharp, Stephen J (författare)
- University of Cambridge
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- Riboli, Elio (författare)
- Imperial College London
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Scott, Robert A (författare)
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- Forouhi, Nita G (författare)
- University of Cambridge
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- Wareham, Nicholas J (författare)
- University of Cambridge
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(creator_code:org_t)
- 2018-03-17
- 2018
- Engelska.
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Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 1432-0428 .- 0012-186X. ; 61:6, s. 1325-1332
- Relaterad länk:
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https://link.springe...
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Gene-macronutrient interactions may contribute to the development of type 2 diabetes but research evidence to date is inconclusive. We aimed to increase our understanding of the aetiology of type 2 diabetes by investigating potential interactions between genes and macronutrient intake and their association with the incidence of type 2 diabetes.We investigated the influence of interactions between genetic risk scores (GRSs) for type 2 diabetes, insulin resistance and BMI and macronutrient intake on the development of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct, a prospective case-cohort study across eight European countries (N=21,900 with 9742 incident type 2 diabetes cases). Macronutrient intake was estimated from diets reported in questionnaires, including proportion of energy derived from total carbohydrate, protein, fat, plant and animal protein, saturated, monounsaturated and polyunsaturated fat and dietary fibre. Using multivariable-adjusted Cox regression, we estimated country-specific interaction results on the multiplicative scale, using random-effects meta-analysis. Secondary analysis used isocaloric macronutrient substitution.No interactions were identified between any of the three GRSs and any macronutrient intake, with low-to-moderate heterogeneity between countries (I2 range 0-51.6%). Results were similar using isocaloric macronutrient substitution analyses and when weighted and unweighted GRSs and individual SNPs were examined.Genetic susceptibility to type 2 diabetes, insulin resistance and BMI did not modify the association between macronutrient intake and incident type 2 diabetes. This suggests that macronutrient intake recommendations to prevent type 2 diabetes do not need to account for differences in genetic predisposition to these three metabolic conditions.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Adult
- Alleles
- Body Mass Index
- Diabetes Mellitus
- Type 2
- epidemiology
- genetics
- Diet
- Dietary Fiber
- Energy Intake
- Europe
- European Continental Ancestry Group
- Female
- Follow-Up Studies
- Genetic Predisposition to Disease
- Humans
- Insulin Resistance
- International Cooperation
- Male
- Middle Aged
- Nutrients
- administration & dosage
- Nutrition Assessment
- Polymorphism
- Single Nucleotide
- Proportional Hazards Models
- Prospective Studies
- Surveys and Questionnaires
- BMI
- BMI
- Body mass index
- Diabetes
- Dietary fibre
- Genetic risk score
- GRS
- Insulin resistance
- Interaction
- Macronutrient
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Li, Sherly X
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Imamura, Fumiaki
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Schulze, Matthia ...
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Zheng, Jusheng
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Ye, Zheng
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Agudo, Antonio
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visa fler...
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Ardanaz, Eva
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Aune, Dagfinn
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Boeing, Heiner
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Dorronsoro, Mire ...
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Dow, Courtney
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Fagherazzi, Guy
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Grioni, Sara
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Gunter, Marc J
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Huerta, José Mar ...
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Ibsen, Daniel B
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Jakobsen, Marian ...
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Kaaks, Rudolf
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Key, Timothy J
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Khaw, Kay-Tee
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Kyrø, Cecilie
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Mancini, Frances ...
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Molina-Portillo, ...
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Murphy, Neil
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Nilsson, Peter M ...
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Onland-Moret, N ...
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Palli, Domenico
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Panico, Salvator ...
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Poveda, Alaitz
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Quirós, J Ramón
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Ricceri, Fulvio
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Sluijs, Ivonne
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Spijkerman, Anne ...
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Tjonneland, Anne
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Tumino, Rosario
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Winkvist, Anna, ...
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Langenberg, Clau ...
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Sharp, Stephen J
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Riboli, Elio
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Scott, Robert A
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Forouhi, Nita G
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Wareham, Nichola ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Näringslära
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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Diabetologia
- Av lärosätet
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Göteborgs universitet
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Umeå universitet
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Lunds universitet