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  • Schmidt, LinnéaUppsala universitet,Neuroonkologi,Science for Life Laboratory, SciLifeLab (author)

Case-specific potentiation of glioblastoma drugs by pterostilbene

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2016-09-28
  • Impact Journals, LLC,2016

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/277076
  • https://gup.ub.gu.se/publication/277076URI
  • https://doi.org/10.18632/oncotarget.12298DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-136745URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-309806URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:134558757URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Glioblastoma multiforme (GBM, astrocytoma grade IV) is the most common malignant primary brain tumor in adults. Addressing the shortage of effective treatment options for this cancer, we explored repurposing of existing drugs into combinations with potent activity against GBM cells. We report that the phytoalexin pterostilbene is a potentiator of two drugs with previously reported anti-GBM activity, the EGFR inhibitor gefitinib and the antidepressant sertraline. Combinations of either of these two compounds with pterostilbene suppress cell growth, viability, sphere formation and inhibit migration in tumor GBM cell (GC) cultures. The potentiating effect of pterostilbene was observed to a varying degree across a panel of 41 patient-derived GCs, and correlated in a case specific manner with the presence of missense mutation of EGFR and PIK3CA and a focal deletion of the chromosomal region 1p32. We identify pterostilbene-induced cell cycle arrest, synergistic inhibition of MAPK activity and induction of Thioredoxin interacting protein (TXNIP) as possible mechanisms behind pterostilbene's effect. Our results highlight a nontoxic stilbenoid compound as a modulator of anticancer drug response, and indicate that pterostilbene might be used to modulate two anticancer compounds in well-defined sets of GBM patients.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Baskaran, SathishkumarUppsala universitet,Neuroonkologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)satsa338 (author)
  • Johansson, PatrikUppsala universitet,Neuroonkologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)patjo183 (author)
  • Padhan, NarendraUppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)narpa396 (author)
  • Matuszewski, Damian J.Uppsala universitet,Avdelningen för visuell information och interaktion,Bildanalys och människa-datorinteraktion(Swepub:uu)damma800 (author)
  • Green, Lydia C.Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center(Swepub:gu)xgrely (author)
  • Elfineh, LudmilaUppsala universitet,Neuroonkologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)liouelfi (author)
  • Wee, S. (author)
  • Häggblad, MariaStockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab)(Swepub:su)maha7002 (author)
  • Martens, UlfStockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab)(Swepub:su)ulma3535 (author)
  • Westermark, BengtUppsala universitet,Neuroonkologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)bengtwm (author)
  • Forsberg-Nilsson, KarinUppsala universitet,Neuroonkologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)karifors (author)
  • Uhrbom, LeneUppsala universitet,Neuroonkologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)leneuhrb (author)
  • Claesson-Welsh, LenaUppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)lcl04207 (author)
  • Andang, M.Karolinska Institutet (author)
  • Sintorn, Ida-MariaUppsala universitet,Avdelningen för visuell information och interaktion,Bildanalys och människa-datorinteraktion(Swepub:uu)idsin102 (author)
  • Lundgren, BoStockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab)(Swepub:su)bolu7255 (author)
  • Lonnstedt, I.Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab (author)
  • Krona, CeciliaUppsala universitet,Neuroonkologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)ceckr429 (author)
  • Nelander, SvenUppsala universitet,Neuroonkologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)svene843 (author)
  • Uppsala universitetNeuroonkologi (creator_code:org_t)

Related titles

  • In:Oncotarget: Impact Journals, LLC7:45, s. 73200-732151949-2553

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