Sökning: id:"swepub:oai:gup.ub.gu.se/277476" >
Identification of P...
-
Henriksson, Anders E.Mittuniversitetet,Avdelningen för naturvetenskap,Sundsvall County Hospital, Sundsvall
(författare)
Identification of Potential Plasma Biomarkers for Abdominal Aortic Aneurysm Using Tandem Mass Tag Quantitative Proteomics
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
-
LIBRIS-ID:oai:gup.ub.gu.se/277476
-
https://gup.ub.gu.se/publication/277476URI
-
https://doi.org/10.3390/proteomes6040043DOI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-35439URI
Kompletterande språkuppgifter
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Plasma biomarkers that identify abdominal aortic aneurysm (AAA) rupture risk would greatly assist in stratifying patients with small aneurysms. Identification of such biomarkers has hitherto been unsuccessful over a range of studies using different methods. The present study used an alternative proteomic approach to find new, potential plasma AAA biomarker candidates. Pre-fractionated plasma samples from twelve patients with AAA and eight matched controls without aneurysm were analyzed by mass spectrometry applying a tandem mass tag (TMT) technique. Eight proteins were differentially regulated in patients compared to controls, including decreased levels of the enzyme bleomycin hydrolase. The down-regulation of this enzyme was confirmed in an extended validation study using an enzyme-linked immunosorbent assay (ELISA). The TMT-based proteomic approach thus identified novel potential plasma biomarkers for AAA.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Lindqvist, M.Sundsvall County Hospital, Sundsvall
(författare)
-
Sihlbom, Carina,1973Gothenburg University,Göteborgs universitet,Core Facilities, Proteomics,Core Facilities, Proteomics,University of Gothenburg, Gothenburg(Swepub:gu)xsihca
(författare)
-
Bergstrom, J.University of Gothenburg, Gothenburg
(författare)
-
Bylund, Dan,1969-Mittuniversitetet,Avdelningen för naturvetenskap(Swepub:miun)danbyl
(författare)
-
MittuniversitetetAvdelningen för naturvetenskap
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Proteomes: MDPI AG6:42227-7382
Internetlänk
Hitta via bibliotek
Till lärosätets databas